diff --git a/packages/cli/src/__tests__/manual-execution.service.test.ts b/packages/cli/src/__tests__/manual-execution.service.test.ts
index 23f69ab821..e9b74172e3 100644
--- a/packages/cli/src/__tests__/manual-execution.service.test.ts
+++ b/packages/cli/src/__tests__/manual-execution.service.test.ts
@@ -1,8 +1,24 @@
 import { mock } from 'jest-mock-extended';
-import type { Workflow, IWorkflowExecutionDataProcess } from 'n8n-workflow';
+import * as core from 'n8n-core';
+import { DirectedGraph, recreateNodeExecutionStack, WorkflowExecute } from 'n8n-core';
+import type {
+	Workflow,
+	IWorkflowExecutionDataProcess,
+	IWorkflowExecuteAdditionalData,
+	IPinData,
+	ITaskData,
+	INode,
+	IRun,
+	IExecuteData,
+	IWaitingForExecution,
+	IWaitingForExecutionSource,
+} from 'n8n-workflow';
+import type PCancelable from 'p-cancelable';
 
 import { ManualExecutionService } from '@/manual-execution.service';
 
+jest.mock('n8n-core');
+
 describe('ManualExecutionService', () => {
 	const manualExecutionService = new ManualExecutionService(mock());
 
@@ -68,4 +84,365 @@ describe('ManualExecutionService', () => {
 			});
 		});
 	});
+
+	describe('runManually', () => {
+		const nodeExecutionStack = mock<IExecuteData[]>();
+		const waitingExecution = mock<IWaitingForExecution>();
+		const waitingExecutionSource = mock<IWaitingForExecutionSource>();
+		const mockFilteredGraph = mock<DirectedGraph>();
+
+		beforeEach(() => {
+			jest.spyOn(DirectedGraph, 'fromWorkflow').mockReturnValue(mock<DirectedGraph>());
+			jest.spyOn(core, 'WorkflowExecute').mockReturnValue(
+				mock<WorkflowExecute>({
+					processRunExecutionData: jest.fn().mockReturnValue(mock<PCancelable<IRun>>()),
+				}),
+			);
+			jest.spyOn(core, 'recreateNodeExecutionStack').mockReturnValue({
+				nodeExecutionStack,
+				waitingExecution,
+				waitingExecutionSource,
+			});
+			jest.spyOn(core, 'filterDisabledNodes').mockReturnValue(mockFilteredGraph);
+		});
+
+		afterEach(() => {
+			jest.resetAllMocks();
+		});
+
+		it('should correctly process triggerToStartFrom data when data.triggerToStartFrom.data is present', async () => {
+			const mockTriggerData = mock<ITaskData>();
+			const startNodeName = 'startNode';
+			const triggerNodeName = 'triggerNode';
+			const data = mock<IWorkflowExecutionDataProcess>({
+				triggerToStartFrom: {
+					name: triggerNodeName,
+					data: mockTriggerData,
+				},
+				startNodes: [{ name: startNodeName }],
+				executionMode: 'manual',
+				pinData: undefined,
+			});
+
+			const startNode = mock<INode>({ name: startNodeName });
+			const workflow = mock<Workflow>({
+				getNode: jest.fn((name) => {
+					if (name === startNodeName) return startNode;
+					return null;
+				}),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+			const pinData: IPinData = {};
+
+			await manualExecutionService.runManually(
+				data,
+				workflow,
+				additionalData,
+				executionId,
+				pinData,
+			);
+
+			expect(DirectedGraph.fromWorkflow).toHaveBeenCalledWith(workflow);
+
+			expect(recreateNodeExecutionStack).toHaveBeenCalledWith(
+				mockFilteredGraph,
+				new Set([startNode]),
+				{ [triggerNodeName]: [mockTriggerData] },
+				{},
+			);
+
+			expect(WorkflowExecute).toHaveBeenCalledWith(
+				additionalData,
+				data.executionMode,
+				expect.objectContaining({
+					resultData: {
+						runData: { [triggerNodeName]: [mockTriggerData] },
+						pinData,
+					},
+					executionData: {
+						contextData: {},
+						metadata: {},
+						nodeExecutionStack,
+						waitingExecution,
+						waitingExecutionSource,
+					},
+				}),
+			);
+		});
+
+		it('should correctly include destinationNode in executionData when provided', async () => {
+			const mockTriggerData = mock<ITaskData>();
+			const startNodeName = 'startNode';
+			const triggerNodeName = 'triggerNode';
+			const destinationNodeName = 'destinationNode';
+
+			const data = mock<IWorkflowExecutionDataProcess>({
+				triggerToStartFrom: {
+					name: triggerNodeName,
+					data: mockTriggerData,
+				},
+				startNodes: [{ name: startNodeName }],
+				executionMode: 'manual',
+				destinationNode: destinationNodeName,
+			});
+
+			const startNode = mock<INode>({ name: startNodeName });
+			const workflow = mock<Workflow>({
+				getNode: jest.fn((name) => {
+					if (name === startNodeName) return startNode;
+					return null;
+				}),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+			const pinData: IPinData = {};
+
+			await manualExecutionService.runManually(
+				data,
+				workflow,
+				additionalData,
+				executionId,
+				pinData,
+			);
+
+			expect(WorkflowExecute).toHaveBeenCalledWith(
+				additionalData,
+				data.executionMode,
+				expect.objectContaining({
+					startData: {
+						destinationNode: destinationNodeName,
+					},
+					resultData: expect.any(Object),
+					executionData: expect.any(Object),
+				}),
+			);
+		});
+
+		it('should call workflowExecute.run for full execution when no runData or startNodes', async () => {
+			const data = mock<IWorkflowExecutionDataProcess>({
+				executionMode: 'manual',
+				destinationNode: undefined,
+				pinData: undefined,
+			});
+
+			const workflow = mock<Workflow>({
+				getNode: jest.fn().mockReturnValue(null),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+
+			const mockRun = jest.fn().mockReturnValue('mockRunReturn');
+			require('n8n-core').WorkflowExecute.mockImplementationOnce(() => ({
+				run: mockRun,
+				processRunExecutionData: jest.fn(),
+			}));
+
+			await manualExecutionService.runManually(data, workflow, additionalData, executionId);
+
+			expect(mockRun).toHaveBeenCalledWith(
+				workflow,
+				undefined, // startNode
+				undefined, // destinationNode
+				undefined, // pinData
+			);
+		});
+
+		it('should use execution start node when available for full execution', async () => {
+			const data = mock<IWorkflowExecutionDataProcess>({
+				executionMode: 'manual',
+				pinData: {},
+				startNodes: [],
+				destinationNode: undefined,
+			});
+
+			const startNode = mock<INode>({ name: 'startNode' });
+			const workflow = mock<Workflow>({
+				getNode: jest.fn().mockReturnValue(startNode),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+			const emptyPinData = {};
+
+			jest.spyOn(manualExecutionService, 'getExecutionStartNode').mockReturnValue(startNode);
+
+			const mockRun = jest.fn().mockReturnValue('mockRunReturn');
+			require('n8n-core').WorkflowExecute.mockImplementationOnce(() => ({
+				run: mockRun,
+				processRunExecutionData: jest.fn(),
+			}));
+
+			await manualExecutionService.runManually(
+				data,
+				workflow,
+				additionalData,
+				executionId,
+				emptyPinData,
+			);
+
+			expect(manualExecutionService.getExecutionStartNode).toHaveBeenCalledWith(data, workflow);
+
+			expect(mockRun).toHaveBeenCalledWith(
+				workflow,
+				startNode, // startNode
+				undefined, // destinationNode
+				data.pinData, // pinData
+			);
+		});
+
+		it('should handle partial execution with provided runData, startNodes and no destinationNode', async () => {
+			const mockRunData = { node1: [{ data: { main: [[{ json: {} }]] } }] };
+			const startNodeName = 'node1';
+			const data = mock<IWorkflowExecutionDataProcess>({
+				executionMode: 'manual',
+				runData: mockRunData,
+				startNodes: [{ name: startNodeName }],
+				destinationNode: undefined,
+				pinData: undefined,
+			});
+
+			const workflow = mock<Workflow>({
+				getNode: jest.fn((name) => {
+					if (name === startNodeName) return mock<INode>({ name: startNodeName });
+					return null;
+				}),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+
+			const mockRunPartialWorkflow = jest.fn().mockReturnValue('mockPartialReturn');
+			require('n8n-core').WorkflowExecute.mockImplementationOnce(() => ({
+				runPartialWorkflow: mockRunPartialWorkflow,
+				processRunExecutionData: jest.fn(),
+			}));
+
+			await manualExecutionService.runManually(data, workflow, additionalData, executionId);
+
+			expect(mockRunPartialWorkflow).toHaveBeenCalledWith(
+				workflow,
+				mockRunData,
+				data.startNodes,
+				undefined, // destinationNode
+				undefined, // pinData
+			);
+		});
+
+		it('should handle partial execution with partialExecutionVersion=2', async () => {
+			const mockRunData = { node1: [{ data: { main: [[{ json: {} }]] } }] };
+			const dirtyNodeNames = ['node2', 'node3'];
+			const destinationNodeName = 'destinationNode';
+			const data = mock<IWorkflowExecutionDataProcess>({
+				executionMode: 'manual',
+				runData: mockRunData,
+				startNodes: [{ name: 'node1' }],
+				partialExecutionVersion: 2,
+				dirtyNodeNames,
+				destinationNode: destinationNodeName,
+			});
+
+			const workflow = mock<Workflow>({
+				getNode: jest.fn((name) => mock<INode>({ name })),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+			const pinData: IPinData = { node1: [{ json: { pinned: true } }] };
+
+			const mockRunPartialWorkflow2 = jest.fn().mockReturnValue('mockPartial2Return');
+			require('n8n-core').WorkflowExecute.mockImplementationOnce(() => ({
+				runPartialWorkflow2: mockRunPartialWorkflow2,
+				processRunExecutionData: jest.fn(),
+			}));
+
+			await manualExecutionService.runManually(
+				data,
+				workflow,
+				additionalData,
+				executionId,
+				pinData,
+			);
+
+			expect(mockRunPartialWorkflow2).toHaveBeenCalled();
+			expect(mockRunPartialWorkflow2.mock.calls[0][0]).toBe(workflow);
+			expect(mockRunPartialWorkflow2.mock.calls[0][4]).toBe(destinationNodeName);
+		});
+
+		it('should validate nodes exist before execution', async () => {
+			const startNodeName = 'existingNode';
+			const data = mock<IWorkflowExecutionDataProcess>({
+				triggerToStartFrom: {
+					name: 'triggerNode',
+					data: mock<ITaskData>(),
+				},
+				startNodes: [{ name: startNodeName }],
+				executionMode: 'manual',
+			});
+
+			const workflow = mock<Workflow>({
+				getNode: jest.fn((name) => {
+					if (name === startNodeName) return mock<INode>({ name: startNodeName });
+					return null;
+				}),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+
+			await manualExecutionService.runManually(data, workflow, additionalData, executionId);
+
+			expect(workflow.getNode).toHaveBeenCalledWith(startNodeName);
+		});
+
+		it('should handle pinData correctly when provided', async () => {
+			const startNodeName = 'startNode';
+			const triggerNodeName = 'triggerNode';
+			const mockTriggerData = mock<ITaskData>();
+			const mockPinData: IPinData = {
+				[startNodeName]: [{ json: { pinned: true } }],
+			};
+
+			const data = mock<IWorkflowExecutionDataProcess>({
+				triggerToStartFrom: {
+					name: triggerNodeName,
+					data: mockTriggerData,
+				},
+				startNodes: [{ name: startNodeName }],
+				executionMode: 'manual',
+			});
+
+			const startNode = mock<INode>({ name: startNodeName });
+			const workflow = mock<Workflow>({
+				getNode: jest.fn((name) => {
+					if (name === startNodeName) return startNode;
+					return null;
+				}),
+			});
+
+			const additionalData = mock<IWorkflowExecuteAdditionalData>();
+			const executionId = 'test-execution-id';
+
+			await manualExecutionService.runManually(
+				data,
+				workflow,
+				additionalData,
+				executionId,
+				mockPinData,
+			);
+
+			expect(WorkflowExecute).toHaveBeenCalledWith(
+				additionalData,
+				data.executionMode,
+				expect.objectContaining({
+					resultData: expect.objectContaining({
+						pinData: mockPinData,
+					}),
+				}),
+			);
+		});
+	});
 });
diff --git a/packages/cli/src/manual-execution.service.ts b/packages/cli/src/manual-execution.service.ts
index 4d6754ff4e..78b7e1723f 100644
--- a/packages/cli/src/manual-execution.service.ts
+++ b/packages/cli/src/manual-execution.service.ts
@@ -48,7 +48,7 @@ export class ManualExecutionService {
 		executionId: string,
 		pinData?: IPinData,
 	): PCancelable<IRun> {
-		if (data.triggerToStartFrom?.data && data.startNodes && !data.destinationNode) {
+		if (data.triggerToStartFrom?.data && data.startNodes) {
 			this.logger.debug(
 				`Execution ID ${executionId} had triggerToStartFrom. Starting from that trigger.`,
 				{ executionId },
@@ -78,6 +78,10 @@ export class ManualExecutionService {
 				},
 			};
 
+			if (data.destinationNode) {
+				executionData.startData = { destinationNode: data.destinationNode };
+			}
+
 			const workflowExecute = new WorkflowExecute(
 				additionalData,
 				data.executionMode,
@@ -105,6 +109,7 @@ export class ManualExecutionService {
 
 			// Can execute without webhook so go on
 			const workflowExecute = new WorkflowExecute(additionalData, data.executionMode);
+
 			return workflowExecute.run(workflow, startNode, data.destinationNode, data.pinData);
 		} else {
 			// Partial Execution