diff --git a/tsdb/block_test.go b/tsdb/block_test.go
index ef19468a34..3a2fe3af91 100644
--- a/tsdb/block_test.go
+++ b/tsdb/block_test.go
@@ -320,7 +320,7 @@ func createBlockFromHead(tb testing.TB, dir string, head *Head) string {
 }
 
 func createHead(tb testing.TB, series []Series) *Head {
-	head, err := NewHead(nil, nil, nil, 2*60*60*1000)
+	head, err := NewHead(nil, nil, nil, 2*60*60*1000, DefaultStripeSize)
 	testutil.Ok(tb, err)
 	defer head.Close()
 
diff --git a/tsdb/compact_test.go b/tsdb/compact_test.go
index d4ebd65b0c..515c3f4ef5 100644
--- a/tsdb/compact_test.go
+++ b/tsdb/compact_test.go
@@ -870,7 +870,7 @@ func BenchmarkCompactionFromHead(b *testing.B) {
 	for labelNames := 1; labelNames < totalSeries; labelNames *= 10 {
 		labelValues := totalSeries / labelNames
 		b.Run(fmt.Sprintf("labelnames=%d,labelvalues=%d", labelNames, labelValues), func(b *testing.B) {
-			h, err := NewHead(nil, nil, nil, 1000)
+			h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 			testutil.Ok(b, err)
 			for ln := 0; ln < labelNames; ln++ {
 				app := h.Appender()
diff --git a/tsdb/db.go b/tsdb/db.go
index c42bda493d..d1cd35cf65 100644
--- a/tsdb/db.go
+++ b/tsdb/db.go
@@ -57,6 +57,7 @@ var DefaultOptions = &Options{
 	NoLockfile:             false,
 	AllowOverlappingBlocks: false,
 	WALCompression:         false,
+	StripeSize:             DefaultStripeSize,
 }
 
 // Options of the DB storage.
@@ -89,6 +90,9 @@ type Options struct {
 
 	// WALCompression will turn on Snappy compression for records on the WAL.
 	WALCompression bool
+
+	// StripeSize is the size in entries of the series hash map. Reducing the size will save memory but impact perfomance.
+	StripeSize int
 }
 
 // Appender allows appending a batch of data. It must be completed with a
@@ -309,7 +313,7 @@ func (db *DBReadOnly) FlushWAL(dir string) error {
 	if err != nil {
 		return err
 	}
-	head, err := NewHead(nil, db.logger, w, 1)
+	head, err := NewHead(nil, db.logger, w, 1, DefaultStripeSize)
 	if err != nil {
 		return err
 	}
@@ -356,7 +360,7 @@ func (db *DBReadOnly) Querier(mint, maxt int64) (Querier, error) {
 		blocks[i] = b
 	}
 
-	head, err := NewHead(nil, db.logger, nil, 1)
+	head, err := NewHead(nil, db.logger, nil, 1, DefaultStripeSize)
 	if err != nil {
 		return nil, err
 	}
@@ -371,7 +375,7 @@ func (db *DBReadOnly) Querier(mint, maxt int64) (Querier, error) {
 		if err != nil {
 			return nil, err
 		}
-		head, err = NewHead(nil, db.logger, w, 1)
+		head, err = NewHead(nil, db.logger, w, 1, DefaultStripeSize)
 		if err != nil {
 			return nil, err
 		}
@@ -488,6 +492,9 @@ func Open(dir string, l log.Logger, r prometheus.Registerer, opts *Options) (db
 	if opts == nil {
 		opts = DefaultOptions
 	}
+	if opts.StripeSize <= 0 {
+		opts.StripeSize = DefaultStripeSize
+	}
 	// Fixup bad format written by Prometheus 2.1.
 	if err := repairBadIndexVersion(l, dir); err != nil {
 		return nil, err
@@ -549,7 +556,7 @@ func Open(dir string, l log.Logger, r prometheus.Registerer, opts *Options) (db
 		}
 	}
 
-	db.head, err = NewHead(r, l, wlog, opts.BlockRanges[0])
+	db.head, err = NewHead(r, l, wlog, opts.BlockRanges[0], opts.StripeSize)
 	if err != nil {
 		return nil, err
 	}
diff --git a/tsdb/head.go b/tsdb/head.go
index 2bf250894b..ce4a367192 100644
--- a/tsdb/head.go
+++ b/tsdb/head.go
@@ -257,7 +257,10 @@ func (h *Head) PostingsCardinalityStats(statsByLabelName string) *index.Postings
 }
 
 // NewHead opens the head block in dir.
-func NewHead(r prometheus.Registerer, l log.Logger, wal *wal.WAL, chunkRange int64) (*Head, error) {
+// stripeSize sets the number of entries in the hash map, it must be a power of 2.
+// A larger stripeSize will allocate more memory up-front, but will increase performance when handling a large number of series.
+// A smaller stripeSize reduces the memory allocated, but can decrease performance with large number of series.
+func NewHead(r prometheus.Registerer, l log.Logger, wal *wal.WAL, chunkRange int64, stripeSize int) (*Head, error) {
 	if l == nil {
 		l = log.NewNopLogger()
 	}
@@ -270,7 +273,7 @@ func NewHead(r prometheus.Registerer, l log.Logger, wal *wal.WAL, chunkRange int
 		chunkRange: chunkRange,
 		minTime:    math.MaxInt64,
 		maxTime:    math.MinInt64,
-		series:     newStripeSeries(),
+		series:     newStripeSeries(stripeSize),
 		values:     map[string]stringset{},
 		symbols:    map[string]struct{}{},
 		postings:   index.NewUnorderedMemPostings(),
@@ -1491,29 +1494,35 @@ func (m seriesHashmap) del(hash uint64, lset labels.Labels) {
 	}
 }
 
+const (
+	// DefaultStripeSize is the default number of entries to allocate in the stripeSeries hash map.
+	DefaultStripeSize = 1 << 14
+)
+
 // stripeSeries locks modulo ranges of IDs and hashes to reduce lock contention.
 // The locks are padded to not be on the same cache line. Filling the padded space
 // with the maps was profiled to be slower – likely due to the additional pointer
 // dereferences.
 type stripeSeries struct {
-	series [stripeSize]map[uint64]*memSeries
-	hashes [stripeSize]seriesHashmap
-	locks  [stripeSize]stripeLock
+	size   int
+	series []map[uint64]*memSeries
+	hashes []seriesHashmap
+	locks  []stripeLock
 }
 
-const (
-	stripeSize = 1 << 14
-	stripeMask = stripeSize - 1
-)
-
 type stripeLock struct {
 	sync.RWMutex
 	// Padding to avoid multiple locks being on the same cache line.
 	_ [40]byte
 }
 
-func newStripeSeries() *stripeSeries {
-	s := &stripeSeries{}
+func newStripeSeries(stripeSize int) *stripeSeries {
+	s := &stripeSeries{
+		size:   stripeSize,
+		series: make([]map[uint64]*memSeries, stripeSize),
+		hashes: make([]seriesHashmap, stripeSize),
+		locks:  make([]stripeLock, stripeSize),
+	}
 
 	for i := range s.series {
 		s.series[i] = map[uint64]*memSeries{}
@@ -1533,7 +1542,7 @@ func (s *stripeSeries) gc(mint int64) (map[uint64]struct{}, int) {
 	)
 	// Run through all series and truncate old chunks. Mark those with no
 	// chunks left as deleted and store their ID.
-	for i := 0; i < stripeSize; i++ {
+	for i := 0; i < s.size; i++ {
 		s.locks[i].Lock()
 
 		for hash, all := range s.hashes[i] {
@@ -1551,7 +1560,7 @@ func (s *stripeSeries) gc(mint int64) (map[uint64]struct{}, int) {
 				// series alike.
 				// If we don't hold them all, there's a very small chance that a series receives
 				// samples again while we are half-way into deleting it.
-				j := int(series.ref & stripeMask)
+				j := int(series.ref) & (s.size - 1)
 
 				if i != j {
 					s.locks[j].Lock()
@@ -1576,7 +1585,7 @@ func (s *stripeSeries) gc(mint int64) (map[uint64]struct{}, int) {
 }
 
 func (s *stripeSeries) getByID(id uint64) *memSeries {
-	i := id & stripeMask
+	i := id & uint64(s.size-1)
 
 	s.locks[i].RLock()
 	series := s.series[i][id]
@@ -1586,7 +1595,7 @@ func (s *stripeSeries) getByID(id uint64) *memSeries {
 }
 
 func (s *stripeSeries) getByHash(hash uint64, lset labels.Labels) *memSeries {
-	i := hash & stripeMask
+	i := hash & uint64(s.size-1)
 
 	s.locks[i].RLock()
 	series := s.hashes[i].get(hash, lset)
@@ -1596,7 +1605,7 @@ func (s *stripeSeries) getByHash(hash uint64, lset labels.Labels) *memSeries {
 }
 
 func (s *stripeSeries) getOrSet(hash uint64, series *memSeries) (*memSeries, bool) {
-	i := hash & stripeMask
+	i := hash & uint64(s.size-1)
 
 	s.locks[i].Lock()
 
@@ -1607,7 +1616,7 @@ func (s *stripeSeries) getOrSet(hash uint64, series *memSeries) (*memSeries, boo
 	s.hashes[i].set(hash, series)
 	s.locks[i].Unlock()
 
-	i = series.ref & stripeMask
+	i = series.ref & uint64(s.size-1)
 
 	s.locks[i].Lock()
 	s.series[i][series.ref] = series
diff --git a/tsdb/head_bench_test.go b/tsdb/head_bench_test.go
index 0f807814ed..c1ada34171 100644
--- a/tsdb/head_bench_test.go
+++ b/tsdb/head_bench_test.go
@@ -24,7 +24,7 @@ import (
 
 func BenchmarkHeadStripeSeriesCreate(b *testing.B) {
 	// Put a series, select it. GC it and then access it.
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(b, err)
 	defer h.Close()
 
@@ -35,7 +35,7 @@ func BenchmarkHeadStripeSeriesCreate(b *testing.B) {
 
 func BenchmarkHeadStripeSeriesCreateParallel(b *testing.B) {
 	// Put a series, select it. GC it and then access it.
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(b, err)
 	defer h.Close()
 
diff --git a/tsdb/head_test.go b/tsdb/head_test.go
index 70a0f56e85..164666db5e 100644
--- a/tsdb/head_test.go
+++ b/tsdb/head_test.go
@@ -41,7 +41,7 @@ import (
 func BenchmarkCreateSeries(b *testing.B) {
 	series := genSeries(b.N, 10, 0, 0)
 
-	h, err := NewHead(nil, nil, nil, 10000)
+	h, err := NewHead(nil, nil, nil, 10000, DefaultStripeSize)
 	testutil.Ok(b, err)
 	defer h.Close()
 
@@ -171,7 +171,7 @@ func BenchmarkLoadWAL(b *testing.B) {
 
 				// Load the WAL.
 				for i := 0; i < b.N; i++ {
-					h, err := NewHead(nil, nil, w, 1000)
+					h, err := NewHead(nil, nil, w, 10000, DefaultStripeSize)
 					testutil.Ok(b, err)
 					h.Init(0)
 				}
@@ -218,7 +218,7 @@ func TestHead_ReadWAL(t *testing.T) {
 			defer w.Close()
 			populateTestWAL(t, w, entries)
 
-			head, err := NewHead(nil, nil, w, 1000)
+			head, err := NewHead(nil, nil, w, 10000, DefaultStripeSize)
 			testutil.Ok(t, err)
 
 			testutil.Ok(t, head.Init(math.MinInt64))
@@ -259,7 +259,7 @@ func TestHead_WALMultiRef(t *testing.T) {
 	w, err := wal.New(nil, nil, dir, false)
 	testutil.Ok(t, err)
 
-	head, err := NewHead(nil, nil, w, 1000)
+	head, err := NewHead(nil, nil, w, 10000, DefaultStripeSize)
 	testutil.Ok(t, err)
 
 	testutil.Ok(t, head.Init(0))
@@ -283,7 +283,7 @@ func TestHead_WALMultiRef(t *testing.T) {
 	w, err = wal.New(nil, nil, dir, false)
 	testutil.Ok(t, err)
 
-	head, err = NewHead(nil, nil, w, 1000)
+	head, err = NewHead(nil, nil, w, 10000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	testutil.Ok(t, head.Init(0))
 	defer head.Close()
@@ -295,7 +295,7 @@ func TestHead_WALMultiRef(t *testing.T) {
 }
 
 func TestHead_Truncate(t *testing.T) {
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 10000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer h.Close()
 
@@ -432,7 +432,7 @@ func TestHeadDeleteSeriesWithoutSamples(t *testing.T) {
 			defer w.Close()
 			populateTestWAL(t, w, entries)
 
-			head, err := NewHead(nil, nil, w, 1000)
+			head, err := NewHead(nil, nil, w, 1000, DefaultStripeSize)
 			testutil.Ok(t, err)
 
 			testutil.Ok(t, head.Init(math.MinInt64))
@@ -506,7 +506,7 @@ func TestHeadDeleteSimple(t *testing.T) {
 				testutil.Ok(t, err)
 				defer w.Close()
 
-				head, err := NewHead(nil, nil, w, 1000)
+				head, err := NewHead(nil, nil, w, 1000, DefaultStripeSize)
 				testutil.Ok(t, err)
 				defer head.Close()
 
@@ -536,7 +536,7 @@ func TestHeadDeleteSimple(t *testing.T) {
 				reloadedW, err := wal.New(nil, nil, w.Dir(), compress) // Use a new wal to ensure deleted samples are gone even after a reload.
 				testutil.Ok(t, err)
 				defer reloadedW.Close()
-				reloadedHead, err := NewHead(nil, nil, reloadedW, 1000)
+				reloadedHead, err := NewHead(nil, nil, reloadedW, 1000, DefaultStripeSize)
 				testutil.Ok(t, err)
 				defer reloadedHead.Close()
 				testutil.Ok(t, reloadedHead.Init(0))
@@ -585,7 +585,7 @@ func TestHeadDeleteSimple(t *testing.T) {
 
 func TestDeleteUntilCurMax(t *testing.T) {
 	numSamples := int64(10)
-	hb, err := NewHead(nil, nil, nil, 1000000)
+	hb, err := NewHead(nil, nil, nil, 1000000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer hb.Close()
 	app := hb.Appender()
@@ -636,7 +636,7 @@ func TestDeletedSamplesAndSeriesStillInWALAfterCheckpoint(t *testing.T) {
 
 	// Enough samples to cause a checkpoint.
 	numSamples := 10000
-	hb, err := NewHead(nil, nil, wlog, int64(numSamples)*10)
+	hb, err := NewHead(nil, nil, wlog, int64(numSamples)*10, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer hb.Close()
 	for i := 0; i < numSamples; i++ {
@@ -730,7 +730,7 @@ func TestDelete_e2e(t *testing.T) {
 	defer func() {
 		testutil.Ok(t, os.RemoveAll(dir))
 	}()
-	hb, err := NewHead(nil, nil, nil, 100000)
+	hb, err := NewHead(nil, nil, nil, 100000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer hb.Close()
 	app := hb.Appender()
@@ -952,7 +952,7 @@ func TestMemSeries_append(t *testing.T) {
 
 func TestGCChunkAccess(t *testing.T) {
 	// Put a chunk, select it. GC it and then access it.
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer h.Close()
 
@@ -992,7 +992,7 @@ func TestGCChunkAccess(t *testing.T) {
 
 func TestGCSeriesAccess(t *testing.T) {
 	// Put a series, select it. GC it and then access it.
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer h.Close()
 
@@ -1033,7 +1033,7 @@ func TestGCSeriesAccess(t *testing.T) {
 }
 
 func TestUncommittedSamplesNotLostOnTruncate(t *testing.T) {
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer h.Close()
 
@@ -1060,7 +1060,7 @@ func TestUncommittedSamplesNotLostOnTruncate(t *testing.T) {
 }
 
 func TestRemoveSeriesAfterRollbackAndTruncate(t *testing.T) {
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer h.Close()
 
@@ -1102,7 +1102,7 @@ func TestHead_LogRollback(t *testing.T) {
 			w, err := wal.New(nil, nil, dir, compress)
 			testutil.Ok(t, err)
 			defer w.Close()
-			h, err := NewHead(nil, nil, w, 1000)
+			h, err := NewHead(nil, nil, w, 1000, DefaultStripeSize)
 			testutil.Ok(t, err)
 
 			app := h.Appender()
@@ -1190,7 +1190,7 @@ func TestWalRepair_DecodingError(t *testing.T) {
 						testutil.Ok(t, w.Log(test.rec))
 					}
 
-					h, err := NewHead(nil, nil, w, 1)
+					h, err := NewHead(nil, nil, w, 1, DefaultStripeSize)
 					testutil.Ok(t, err)
 					testutil.Equals(t, 0.0, prom_testutil.ToFloat64(h.metrics.walCorruptionsTotal))
 					initErr := h.Init(math.MinInt64)
@@ -1239,7 +1239,7 @@ func TestNewWalSegmentOnTruncate(t *testing.T) {
 	wlog, err := wal.NewSize(nil, nil, dir, 32768, false)
 	testutil.Ok(t, err)
 
-	h, err := NewHead(nil, nil, wlog, 1000)
+	h, err := NewHead(nil, nil, wlog, 1000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer h.Close()
 	add := func(ts int64) {
diff --git a/tsdb/querier_bench_test.go b/tsdb/querier_bench_test.go
index 39f3b7c901..bd7364b451 100644
--- a/tsdb/querier_bench_test.go
+++ b/tsdb/querier_bench_test.go
@@ -30,7 +30,7 @@ const (
 )
 
 func BenchmarkPostingsForMatchers(b *testing.B) {
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(b, err)
 	defer func() {
 		testutil.Ok(b, h.Close())
@@ -126,7 +126,7 @@ func benchmarkPostingsForMatchers(b *testing.B, ir IndexReader) {
 }
 
 func BenchmarkQuerierSelect(b *testing.B) {
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(b, err)
 	defer h.Close()
 	app := h.Appender()
diff --git a/tsdb/querier_test.go b/tsdb/querier_test.go
index 44782ce86e..f391dc7917 100644
--- a/tsdb/querier_test.go
+++ b/tsdb/querier_test.go
@@ -1812,7 +1812,7 @@ func TestFindSetMatches(t *testing.T) {
 }
 
 func TestPostingsForMatchers(t *testing.T) {
-	h, err := NewHead(nil, nil, nil, 1000)
+	h, err := NewHead(nil, nil, nil, 1000, DefaultStripeSize)
 	testutil.Ok(t, err)
 	defer func() {
 		testutil.Ok(t, h.Close())
diff --git a/tsdb/tsdbblockutil.go b/tsdb/tsdbblockutil.go
index eb17560195..891876bcaa 100644
--- a/tsdb/tsdbblockutil.go
+++ b/tsdb/tsdbblockutil.go
@@ -16,10 +16,11 @@ package tsdb
 import (
 	"context"
 	"fmt"
-	"github.com/go-kit/kit/log"
-	"github.com/prometheus/prometheus/pkg/labels"
 	"os"
 	"path/filepath"
+
+	"github.com/go-kit/kit/log"
+	"github.com/prometheus/prometheus/pkg/labels"
 )
 
 var InvalidTimesError = fmt.Errorf("max time is lesser than min time")
@@ -32,7 +33,7 @@ type MetricSample struct {
 
 // CreateHead creates a TSDB writer head to write the sample data to.
 func CreateHead(samples []*MetricSample, chunkRange int64, logger log.Logger) (*Head, error) {
-	head, err := NewHead(nil, logger, nil, chunkRange)
+	head, err := NewHead(nil, logger, nil, chunkRange, DefaultStripeSize)
 	if err != nil {
 		return nil, err
 	}
diff --git a/web/api/v1/api_test.go b/web/api/v1/api_test.go
index fd6d490003..bc4d710584 100644
--- a/web/api/v1/api_test.go
+++ b/web/api/v1/api_test.go
@@ -1877,7 +1877,7 @@ func (f *fakeDB) Dir() string {
 }
 func (f *fakeDB) Snapshot(dir string, withHead bool) error { return f.err }
 func (f *fakeDB) Head() *tsdb.Head {
-	h, _ := tsdb.NewHead(nil, nil, nil, 1000)
+	h, _ := tsdb.NewHead(nil, nil, nil, 1000, tsdb.DefaultStripeSize)
 	return h
 }