diff --git a/web/ui/react-app/public/index.html b/web/ui/react-app/public/index.html
index cc3336fa25..c19bb569bf 100755
--- a/web/ui/react-app/public/index.html
+++ b/web/ui/react-app/public/index.html
@@ -10,16 +10,11 @@
     <meta name="theme-color" content="#000000" />
 
     <!--
-      The GLOBAL_PATH_PREFIX placeholder magic value is replaced during serving by Prometheus
-      and set to Prometheus's external URL path. It gets prepended to all links back
-      to Prometheus, both for asset loading as well as API accesses.
-
       The GLOBAL_CONSOLES_LINK placeholder magic value is replaced during serving by Prometheus
       and set to the consoles link if it exists. It will render a "Consoles" link in the navbar when
       it is non-empty.
     -->
     <script>
-      const GLOBAL_PATH_PREFIX='PATH_PREFIX_PLACEHOLDER';
       const GLOBAL_CONSOLES_LINK='CONSOLES_LINK_PLACEHOLDER';
     </script>
 
diff --git a/web/ui/react-app/src/App.test.tsx b/web/ui/react-app/src/App.test.tsx
index 705e0bc6b8..e96bbf7a40 100755
--- a/web/ui/react-app/src/App.test.tsx
+++ b/web/ui/react-app/src/App.test.tsx
@@ -7,7 +7,7 @@ import { Router } from '@reach/router';
 import { Alerts, Config, Flags, Rules, ServiceDiscovery, Status, Targets, TSDBStatus, PanelList } from './pages';
 
 describe('App', () => {
-  const app = shallow(<App pathPrefix="/path/prefix" />);
+  const app = shallow(<App />);
 
   it('navigates', () => {
     expect(app.find(Navigation)).toHaveLength(1);
@@ -16,7 +16,6 @@ describe('App', () => {
     [Alerts, Config, Flags, Rules, ServiceDiscovery, Status, Targets, TSDBStatus, PanelList].forEach(component => {
       const c = app.find(component);
       expect(c).toHaveLength(1);
-      expect(c.prop('pathPrefix')).toBe('/path/prefix');
     });
     expect(app.find(Router)).toHaveLength(1);
     expect(app.find(Container)).toHaveLength(1);
diff --git a/web/ui/react-app/src/App.tsx b/web/ui/react-app/src/App.tsx
index d172773e0d..29adb54b6f 100755
--- a/web/ui/react-app/src/App.tsx
+++ b/web/ui/react-app/src/App.tsx
@@ -5,36 +5,62 @@ import { Container } from 'reactstrap';
 import './App.css';
 import { Router, Redirect } from '@reach/router';
 import { Alerts, Config, Flags, Rules, ServiceDiscovery, Status, Targets, TSDBStatus, PanelList } from './pages';
-import PathPrefixProps from './types/PathPrefixProps';
+import { PathPrefixContext } from './contexts/PathPrefixContext';
 
 interface AppProps {
   consolesLink: string | null;
 }
 
-const App: FC<PathPrefixProps & AppProps> = ({ pathPrefix, consolesLink }) => {
-  return (
-    <>
-      <Navigation pathPrefix={pathPrefix} consolesLink={consolesLink} />
-      <Container fluid style={{ paddingTop: 70 }}>
-        <Router basepath={`${pathPrefix}/new`}>
-          <Redirect from="/" to={`${pathPrefix}/new/graph`} />
+const App: FC<AppProps> = ({ consolesLink }) => {
+  // This dynamically/generically determines the pathPrefix by stripping the first known
+  // endpoint suffix from the window location path. It works out of the box for both direct
+  // hosting and reverse proxy deployments with no additional configurations required.
+  let basePath = window.location.pathname;
+  const paths = [
+    '/graph',
+    '/alerts',
+    '/status',
+    '/tsdb-status',
+    '/flags',
+    '/config',
+    '/rules',
+    '/targets',
+    '/service-discovery',
+  ];
+  if (basePath.endsWith('/')) {
+    basePath = basePath.slice(0, -1);
+  }
+  if (basePath.length > 1) {
+    for (let i = 0; i < paths.length; i++) {
+      if (basePath.endsWith(paths[i])) {
+        basePath = basePath.slice(0, basePath.length - paths[i].length);
+        break;
+      }
+    }
+  }
 
+  return (
+    <PathPrefixContext.Provider value={basePath}>
+      <Navigation consolesLink={consolesLink} />
+      <Container fluid style={{ paddingTop: 70 }}>
+        <Router basepath={`${basePath}`}>
+          <Redirect from="/" to={`graph`} noThrow />
           {/*
-            NOTE: Any route added here needs to also be added to the list of
-            React-handled router paths ("reactRouterPaths") in /web/web.go.
-          */}
-          <PanelList path="/graph" pathPrefix={pathPrefix} />
-          <Alerts path="/alerts" pathPrefix={pathPrefix} />
-          <Config path="/config" pathPrefix={pathPrefix} />
-          <Flags path="/flags" pathPrefix={pathPrefix} />
-          <Rules path="/rules" pathPrefix={pathPrefix} />
-          <ServiceDiscovery path="/service-discovery" pathPrefix={pathPrefix} />
-          <Status path="/status" pathPrefix={pathPrefix} />
-          <TSDBStatus path="/tsdb-status" pathPrefix={pathPrefix} />
-          <Targets path="/targets" pathPrefix={pathPrefix} />
+              NOTE: Any route added here needs to also be added to the list of
+              React-handled router paths ("reactRouterPaths") in /web/web.go.
+            */}
+          <PanelList path="/graph" />
+          <Alerts path="/alerts" />
+          <Config path="/config" />
+          <Flags path="/flags" />
+          <Rules path="/rules" />
+          <ServiceDiscovery path="/service-discovery" />
+          <Status path="/status" />
+          <TSDBStatus path="/tsdb-status" />
+          <Targets path="/targets" />
         </Router>
       </Container>
-    </>
+    </PathPrefixContext.Provider>
   );
 };
 
diff --git a/web/ui/react-app/src/Navbar.tsx b/web/ui/react-app/src/Navbar.tsx
index 51c072add4..a425c33cb2 100644
--- a/web/ui/react-app/src/Navbar.tsx
+++ b/web/ui/react-app/src/Navbar.tsx
@@ -12,19 +12,20 @@ import {
   DropdownMenu,
   DropdownItem,
 } from 'reactstrap';
-import PathPrefixProps from './types/PathPrefixProps';
+import { usePathPrefix } from './contexts/PathPrefixContext';
 
 interface NavbarProps {
   consolesLink: string | null;
 }
 
-const Navigation: FC<PathPrefixProps & NavbarProps> = ({ pathPrefix, consolesLink }) => {
+const Navigation: FC<NavbarProps> = ({ consolesLink }) => {
   const [isOpen, setIsOpen] = useState(false);
   const toggle = () => setIsOpen(!isOpen);
+  const pathPrefix = usePathPrefix();
   return (
     <Navbar className="mb-3" dark color="dark" expand="md" fixed="top">
       <NavbarToggler onClick={toggle} />
-      <Link className="pt-0 navbar-brand" to={`${pathPrefix}/new/graph`}>
+      <Link className="pt-0 navbar-brand" to={`${pathPrefix}/graph`}>
         Prometheus
       </Link>
       <Collapse isOpen={isOpen} navbar style={{ justifyContent: 'space-between' }}>
@@ -35,12 +36,12 @@ const Navigation: FC<PathPrefixProps & NavbarProps> = ({ pathPrefix, consolesLin
             </NavItem>
           )}
           <NavItem>
-            <NavLink tag={Link} to={`${pathPrefix}/new/alerts`}>
+            <NavLink tag={Link} to={`${pathPrefix}/alerts`}>
               Alerts
             </NavLink>
           </NavItem>
           <NavItem>
-            <NavLink tag={Link} to={`${pathPrefix}/new/graph`}>
+            <NavLink tag={Link} to={`${pathPrefix}/graph`}>
               Graph
             </NavLink>
           </NavItem>
@@ -49,25 +50,25 @@ const Navigation: FC<PathPrefixProps & NavbarProps> = ({ pathPrefix, consolesLin
               Status
             </DropdownToggle>
             <DropdownMenu>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/status`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/status`}>
                 Runtime & Build Information
               </DropdownItem>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/tsdb-status`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/tsdb-status`}>
                 TSDB Status
               </DropdownItem>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/flags`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/flags`}>
                 Command-Line Flags
               </DropdownItem>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/config`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/config`}>
                 Configuration
               </DropdownItem>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/rules`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/rules`}>
                 Rules
               </DropdownItem>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/targets`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/targets`}>
                 Targets
               </DropdownItem>
-              <DropdownItem tag={Link} to={`${pathPrefix}/new/service-discovery`}>
+              <DropdownItem tag={Link} to={`${pathPrefix}/service-discovery`}>
                 Service Discovery
               </DropdownItem>
             </DropdownMenu>
@@ -76,7 +77,7 @@ const Navigation: FC<PathPrefixProps & NavbarProps> = ({ pathPrefix, consolesLin
             <NavLink href="https://prometheus.io/docs/prometheus/latest/getting_started/">Help</NavLink>
           </NavItem>
           <NavItem>
-            <NavLink href={`${pathPrefix}/graph${window.location.search}`}>Classic UI</NavLink>
+            <NavLink href={`${pathPrefix}/../graph${window.location.search}`}>Classic UI</NavLink>
           </NavItem>
         </Nav>
       </Collapse>
diff --git a/web/ui/react-app/src/constants/constants.tsx b/web/ui/react-app/src/constants/constants.tsx
new file mode 100644
index 0000000000..5f0d8b9b4a
--- /dev/null
+++ b/web/ui/react-app/src/constants/constants.tsx
@@ -0,0 +1 @@
+export const API_PATH = '../api/v1';
diff --git a/web/ui/react-app/src/contexts/PathPrefixContext.tsx b/web/ui/react-app/src/contexts/PathPrefixContext.tsx
new file mode 100644
index 0000000000..38e4eec096
--- /dev/null
+++ b/web/ui/react-app/src/contexts/PathPrefixContext.tsx
@@ -0,0 +1,9 @@
+import React from 'react';
+
+const PathPrefixContext = React.createContext('');
+
+function usePathPrefix() {
+  return React.useContext(PathPrefixContext);
+}
+
+export { usePathPrefix, PathPrefixContext };
diff --git a/web/ui/react-app/src/index.tsx b/web/ui/react-app/src/index.tsx
index f6e672829a..9398bc8983 100755
--- a/web/ui/react-app/src/index.tsx
+++ b/web/ui/react-app/src/index.tsx
@@ -6,20 +6,10 @@ import 'bootstrap/dist/css/bootstrap.min.css';
 import { isPresent } from './utils';
 
 // Declared/defined in public/index.html, value replaced by Prometheus when serving bundle.
-declare const GLOBAL_PATH_PREFIX: string;
 declare const GLOBAL_CONSOLES_LINK: string;
 
-let prefix = GLOBAL_PATH_PREFIX;
 let consolesLink: string | null = GLOBAL_CONSOLES_LINK;
 
-if (GLOBAL_PATH_PREFIX === 'PATH_PREFIX_PLACEHOLDER' || GLOBAL_PATH_PREFIX === '/' || !isPresent(GLOBAL_PATH_PREFIX)) {
-  // Either we are running the app outside of Prometheus, so the placeholder value in
-  // the index.html didn't get replaced, or we have a '/' prefix, which we also need to
-  // normalize to '' to make concatenations work (prefixes like '/foo/bar/' already get
-  // their trailing slash stripped by Prometheus).
-  prefix = '';
-}
-
 if (
   GLOBAL_CONSOLES_LINK === 'CONSOLES_LINK_PLACEHOLDER' ||
   GLOBAL_CONSOLES_LINK === '' ||
@@ -28,4 +18,4 @@ if (
   consolesLink = null;
 }
 
-ReactDOM.render(<App pathPrefix={prefix} consolesLink={consolesLink} />, document.getElementById('root'));
+ReactDOM.render(<App consolesLink={consolesLink} />, document.getElementById('root'));
diff --git a/web/ui/react-app/src/pages/alerts/Alerts.tsx b/web/ui/react-app/src/pages/alerts/Alerts.tsx
index c6fef5b767..a1624d7a87 100644
--- a/web/ui/react-app/src/pages/alerts/Alerts.tsx
+++ b/web/ui/react-app/src/pages/alerts/Alerts.tsx
@@ -1,14 +1,16 @@
 import React, { FC } from 'react';
 import { RouteComponentProps } from '@reach/router';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { useFetch } from '../../hooks/useFetch';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
 import AlertsContent, { RuleStatus, AlertsProps } from './AlertContents';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 const AlertsWithStatusIndicator = withStatusIndicator(AlertsContent);
 
-const Alerts: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix = '' }) => {
-  const { response, error, isLoading } = useFetch<AlertsProps>(`${pathPrefix}/api/v1/rules?type=alert`);
+const Alerts: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const { response, error, isLoading } = useFetch<AlertsProps>(`${pathPrefix}/${API_PATH}/rules?type=alert`);
 
   const ruleStatsCount: RuleStatus<number> = {
     inactive: 0,
diff --git a/web/ui/react-app/src/pages/config/Config.tsx b/web/ui/react-app/src/pages/config/Config.tsx
index 1636668e6c..00bb56d19c 100644
--- a/web/ui/react-app/src/pages/config/Config.tsx
+++ b/web/ui/react-app/src/pages/config/Config.tsx
@@ -2,11 +2,12 @@ import React, { useState, FC } from 'react';
 import { RouteComponentProps } from '@reach/router';
 import { Button } from 'reactstrap';
 import CopyToClipboard from 'react-copy-to-clipboard';
-import PathPrefixProps from '../../types/PathPrefixProps';
 
 import './Config.css';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
 import { useFetch } from '../../hooks/useFetch';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 type YamlConfig = { yaml?: string };
 
@@ -44,8 +45,9 @@ export const ConfigContent: FC<ConfigContentProps> = ({ error, data }) => {
   );
 };
 
-const Config: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix }) => {
-  const { response, error } = useFetch<YamlConfig>(`${pathPrefix}/api/v1/status/config`);
+const Config: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const { response, error } = useFetch<YamlConfig>(`${pathPrefix}/${API_PATH}/status/config`);
   return <ConfigContent error={error} data={response.data} />;
 };
 
diff --git a/web/ui/react-app/src/pages/flags/Flags.tsx b/web/ui/react-app/src/pages/flags/Flags.tsx
index 5f0a409650..60b67ae771 100644
--- a/web/ui/react-app/src/pages/flags/Flags.tsx
+++ b/web/ui/react-app/src/pages/flags/Flags.tsx
@@ -3,7 +3,8 @@ import { RouteComponentProps } from '@reach/router';
 import { Table } from 'reactstrap';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
 import { useFetch } from '../../hooks/useFetch';
-import PathPrefixProps from '../../types/PathPrefixProps';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 interface FlagMap {
   [key: string]: string;
@@ -34,8 +35,9 @@ const FlagsWithStatusIndicator = withStatusIndicator(FlagsContent);
 
 FlagsContent.displayName = 'Flags';
 
-const Flags: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix = '' }) => {
-  const { response, error, isLoading } = useFetch<FlagMap>(`${pathPrefix}/api/v1/status/flags`);
+const Flags: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const { response, error, isLoading } = useFetch<FlagMap>(`${pathPrefix}/${API_PATH}/status/flags`);
   return <FlagsWithStatusIndicator data={response.data} error={error} isLoading={isLoading} />;
 };
 
diff --git a/web/ui/react-app/src/pages/graph/Panel.tsx b/web/ui/react-app/src/pages/graph/Panel.tsx
index 29dbbc4dc7..bd103de4d2 100644
--- a/web/ui/react-app/src/pages/graph/Panel.tsx
+++ b/web/ui/react-app/src/pages/graph/Panel.tsx
@@ -10,8 +10,8 @@ import { GraphTabContent } from './GraphTabContent';
 import DataTable from './DataTable';
 import TimeInput from './TimeInput';
 import QueryStatsView, { QueryStats } from './QueryStatsView';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { QueryParams } from '../../types/types';
+import { API_PATH } from '../../constants/constants';
 
 interface PanelProps {
   options: PanelOptions;
@@ -21,6 +21,7 @@ interface PanelProps {
   metricNames: string[];
   removePanel: () => void;
   onExecuteQuery: (query: string) => void;
+  pathPrefix: string;
 }
 
 interface PanelState {
@@ -55,7 +56,7 @@ export const PanelDefaultOptions: PanelOptions = {
   stacked: false,
 };
 
-class Panel extends Component<PanelProps & PathPrefixProps, PanelState> {
+class Panel extends Component<PanelProps, PanelState> {
   private abortInFlightFetch: (() => void) | null = null;
 
   constructor(props: PanelProps) {
@@ -117,21 +118,20 @@ class Panel extends Component<PanelProps & PathPrefixProps, PanelState> {
     let path: string;
     switch (this.props.options.type) {
       case 'graph':
-        path = '/api/v1/query_range';
+        path = 'query_range';
         params.append('start', startTime.toString());
         params.append('end', endTime.toString());
         params.append('step', resolution.toString());
-        // TODO path prefix here and elsewhere.
         break;
       case 'table':
-        path = '/api/v1/query';
+        path = 'query';
         params.append('time', endTime.toString());
         break;
       default:
         throw new Error('Invalid panel type "' + this.props.options.type + '"');
     }
 
-    fetch(`${this.props.pathPrefix}${path}?${params}`, {
+    fetch(`${this.props.pathPrefix}/${API_PATH}/${path}?${params}`, {
       cache: 'no-store',
       credentials: 'same-origin',
       signal: abortController.signal,
diff --git a/web/ui/react-app/src/pages/graph/PanelList.tsx b/web/ui/react-app/src/pages/graph/PanelList.tsx
index 8444b09872..b8e29bcb0f 100644
--- a/web/ui/react-app/src/pages/graph/PanelList.tsx
+++ b/web/ui/react-app/src/pages/graph/PanelList.tsx
@@ -4,10 +4,11 @@ import { Alert, Button } from 'reactstrap';
 
 import Panel, { PanelOptions, PanelDefaultOptions } from './Panel';
 import Checkbox from '../../components/Checkbox';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { generateID, decodePanelOptionsFromQueryString, encodePanelOptionsToQueryString, callAll } from '../../utils';
 import { useFetch } from '../../hooks/useFetch';
 import { useLocalStorage } from '../../hooks/useLocalStorage';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 export type PanelMeta = { key: string; options: PanelOptions; id: string };
 
@@ -16,20 +17,14 @@ export const updateURL = (nextPanels: PanelMeta[]) => {
   window.history.pushState({}, '', query);
 };
 
-interface PanelListProps extends PathPrefixProps, RouteComponentProps {
+interface PanelListProps extends RouteComponentProps {
   panels: PanelMeta[];
   metrics: string[];
   useLocalTime: boolean;
   queryHistoryEnabled: boolean;
 }
 
-export const PanelListContent: FC<PanelListProps> = ({
-  metrics = [],
-  useLocalTime,
-  pathPrefix,
-  queryHistoryEnabled,
-  ...rest
-}) => {
+export const PanelListContent: FC<PanelListProps> = ({ metrics = [], useLocalTime, queryHistoryEnabled, ...rest }) => {
   const [panels, setPanels] = useState(rest.panels);
   const [historyItems, setLocalStorageHistoryItems] = useLocalStorage<string[]>('history', []);
 
@@ -73,10 +68,13 @@ export const PanelListContent: FC<PanelListProps> = ({
     ]);
   };
 
+  const pathPrefix = usePathPrefix();
+
   return (
     <>
       {panels.map(({ id, options }) => (
         <Panel
+          pathPrefix={pathPrefix}
           onExecuteQuery={handleExecuteQuery}
           key={id}
           options={options}
@@ -97,7 +95,6 @@ export const PanelListContent: FC<PanelListProps> = ({
           useLocalTime={useLocalTime}
           metricNames={metrics}
           pastQueries={queryHistoryEnabled ? historyItems : []}
-          pathPrefix={pathPrefix}
         />
       ))}
       <Button className="mb-3" color="primary" onClick={addPanel}>
@@ -107,15 +104,18 @@ export const PanelListContent: FC<PanelListProps> = ({
   );
 };
 
-const PanelList: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix = '' }) => {
+const PanelList: FC<RouteComponentProps> = () => {
   const [delta, setDelta] = useState(0);
   const [useLocalTime, setUseLocalTime] = useLocalStorage('use-local-time', false);
   const [enableQueryHistory, setEnableQueryHistory] = useLocalStorage('enable-query-history', false);
 
-  const { response: metricsRes, error: metricsErr } = useFetch<string[]>(`${pathPrefix}/api/v1/label/__name__/values`);
+  const pathPrefix = usePathPrefix();
+  const { response: metricsRes, error: metricsErr } = useFetch<string[]>(`${pathPrefix}/${API_PATH}/label/__name__/values`);
 
   const browserTime = new Date().getTime() / 1000;
-  const { response: timeRes, error: timeErr } = useFetch<{ result: number[] }>(`${pathPrefix}/api/v1/query?query=time()`);
+  const { response: timeRes, error: timeErr } = useFetch<{ result: number[] }>(
+    `${pathPrefix}/${API_PATH}/query?query=time()`
+  );
 
   useEffect(() => {
     if (timeRes.data) {
@@ -164,7 +164,6 @@ const PanelList: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix = ''
       )}
       <PanelListContent
         panels={decodePanelOptionsFromQueryString(window.location.search)}
-        pathPrefix={pathPrefix}
         useLocalTime={useLocalTime}
         metrics={metricsRes.data}
         queryHistoryEnabled={enableQueryHistory}
diff --git a/web/ui/react-app/src/pages/rules/Rules.tsx b/web/ui/react-app/src/pages/rules/Rules.tsx
index a44a721f53..3a849fb92d 100644
--- a/web/ui/react-app/src/pages/rules/Rules.tsx
+++ b/web/ui/react-app/src/pages/rules/Rules.tsx
@@ -1,14 +1,16 @@
 import React, { FC } from 'react';
 import { RouteComponentProps } from '@reach/router';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { useFetch } from '../../hooks/useFetch';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
 import { RulesMap, RulesContent } from './RulesContent';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 const RulesWithStatusIndicator = withStatusIndicator(RulesContent);
 
-const Rules: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix }) => {
-  const { response, error, isLoading } = useFetch<RulesMap>(`${pathPrefix}/api/v1/rules`);
+const Rules: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const { response, error, isLoading } = useFetch<RulesMap>(`${pathPrefix}/${API_PATH}/rules`);
 
   return <RulesWithStatusIndicator response={response} error={error} isLoading={isLoading} />;
 };
diff --git a/web/ui/react-app/src/pages/serviceDiscovery/Services.tsx b/web/ui/react-app/src/pages/serviceDiscovery/Services.tsx
index 87aabb17ad..f2892dab61 100644
--- a/web/ui/react-app/src/pages/serviceDiscovery/Services.tsx
+++ b/web/ui/react-app/src/pages/serviceDiscovery/Services.tsx
@@ -1,12 +1,13 @@
 import React, { FC } from 'react';
 import { RouteComponentProps } from '@reach/router';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { useFetch } from '../../hooks/useFetch';
 import { LabelsTable } from './LabelsTable';
 import { Target, Labels, DroppedTarget } from '../targets/target';
 
 import { withStatusIndicator } from '../../components/withStatusIndicator';
 import { mapObjEntries } from '../../utils';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 interface ServiceMap {
   activeTargets: Target[];
@@ -105,8 +106,9 @@ ServiceDiscoveryContent.displayName = 'ServiceDiscoveryContent';
 
 const ServicesWithStatusIndicator = withStatusIndicator(ServiceDiscoveryContent);
 
-const ServiceDiscovery: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix }) => {
-  const { response, error, isLoading } = useFetch<ServiceMap>(`${pathPrefix}/api/v1/targets`);
+const ServiceDiscovery: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const { response, error, isLoading } = useFetch<ServiceMap>(`${pathPrefix}/${API_PATH}/targets`);
   return (
     <ServicesWithStatusIndicator
       {...response.data}
diff --git a/web/ui/react-app/src/pages/status/Status.tsx b/web/ui/react-app/src/pages/status/Status.tsx
index a6eb0da58e..518662cffe 100644
--- a/web/ui/react-app/src/pages/status/Status.tsx
+++ b/web/ui/react-app/src/pages/status/Status.tsx
@@ -3,7 +3,8 @@ import { RouteComponentProps } from '@reach/router';
 import { Table } from 'reactstrap';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
 import { useFetch } from '../../hooks/useFetch';
-import PathPrefixProps from '../../types/PathPrefixProps';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 interface StatusPageProps {
   data: Record<string, string>;
@@ -82,8 +83,9 @@ const StatusWithStatusIndicator = withStatusIndicator(StatusContent);
 
 StatusContent.displayName = 'Status';
 
-const Status: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix = '' }) => {
-  const path = `${pathPrefix}/api/v1`;
+const Status: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const path = `${pathPrefix}/${API_PATH}`;
 
   return (
     <>
diff --git a/web/ui/react-app/src/pages/targets/ScrapePoolList.test.tsx b/web/ui/react-app/src/pages/targets/ScrapePoolList.test.tsx
index be57f4c8a1..c46dbfc080 100644
--- a/web/ui/react-app/src/pages/targets/ScrapePoolList.test.tsx
+++ b/web/ui/react-app/src/pages/targets/ScrapePoolList.test.tsx
@@ -7,11 +7,11 @@ import ScrapePoolList from './ScrapePoolList';
 import ScrapePoolPanel from './ScrapePoolPanel';
 import { Target } from './target';
 import { FetchMock } from 'jest-fetch-mock/types';
+import { PathPrefixContext } from '../../contexts/PathPrefixContext';
 
 describe('ScrapePoolList', () => {
   const defaultProps = {
     filter: { showHealthy: true, showUnhealthy: true },
-    pathPrefix: '..',
   };
 
   beforeEach(() => {
@@ -36,10 +36,17 @@ describe('ScrapePoolList', () => {
 
     it('renders a table', async () => {
       await act(async () => {
-        scrapePoolList = mount(<ScrapePoolList {...defaultProps} />);
+        scrapePoolList = mount(
+          <PathPrefixContext.Provider value="/path/prefix">
+            <ScrapePoolList {...defaultProps} />
+          </PathPrefixContext.Provider>
+        );
       });
       scrapePoolList.update();
-      expect(mock).toHaveBeenCalledWith('../api/v1/targets?state=active', { cache: 'no-store', credentials: 'same-origin' });
+      expect(mock).toHaveBeenCalledWith('/path/prefix/../api/v1/targets?state=active', {
+        cache: 'no-store',
+        credentials: 'same-origin',
+      });
       const panels = scrapePoolList.find(ScrapePoolPanel);
       expect(panels).toHaveLength(3);
       const activeTargets: Target[] = sampleApiResponse.data.activeTargets as Target[];
@@ -55,10 +62,17 @@ describe('ScrapePoolList', () => {
         filter: { showHealthy: false, showUnhealthy: true },
       };
       await act(async () => {
-        scrapePoolList = mount(<ScrapePoolList {...props} />);
+        scrapePoolList = mount(
+          <PathPrefixContext.Provider value="/path/prefix">
+            <ScrapePoolList {...props} />
+          </PathPrefixContext.Provider>
+        );
       });
       scrapePoolList.update();
-      expect(mock).toHaveBeenCalledWith('../api/v1/targets?state=active', { cache: 'no-store', credentials: 'same-origin' });
+      expect(mock).toHaveBeenCalledWith('/path/prefix/../api/v1/targets?state=active', {
+        cache: 'no-store',
+        credentials: 'same-origin',
+      });
       const panels = scrapePoolList.find(ScrapePoolPanel);
       expect(panels).toHaveLength(0);
     });
@@ -70,11 +84,18 @@ describe('ScrapePoolList', () => {
 
       let scrapePoolList: any;
       await act(async () => {
-        scrapePoolList = mount(<ScrapePoolList {...defaultProps} />);
+        scrapePoolList = mount(
+          <PathPrefixContext.Provider value="/path/prefix">
+            <ScrapePoolList {...defaultProps} />
+          </PathPrefixContext.Provider>
+        );
       });
       scrapePoolList.update();
 
-      expect(mock).toHaveBeenCalledWith('../api/v1/targets?state=active', { cache: 'no-store', credentials: 'same-origin' });
+      expect(mock).toHaveBeenCalledWith('/path/prefix/../api/v1/targets?state=active', {
+        cache: 'no-store',
+        credentials: 'same-origin',
+      });
       const alert = scrapePoolList.find(Alert);
       expect(alert.prop('color')).toBe('danger');
       expect(alert.text()).toContain('Error fetching targets');
diff --git a/web/ui/react-app/src/pages/targets/ScrapePoolList.tsx b/web/ui/react-app/src/pages/targets/ScrapePoolList.tsx
index 7be82f1fce..8e55f82fc5 100644
--- a/web/ui/react-app/src/pages/targets/ScrapePoolList.tsx
+++ b/web/ui/react-app/src/pages/targets/ScrapePoolList.tsx
@@ -3,8 +3,9 @@ import { FilterData } from './Filter';
 import { useFetch } from '../../hooks/useFetch';
 import { groupTargets, Target } from './target';
 import ScrapePoolPanel from './ScrapePoolPanel';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 interface ScrapePoolListProps {
   filter: FilterData;
@@ -30,8 +31,9 @@ ScrapePoolContent.displayName = 'ScrapePoolContent';
 
 const ScrapePoolListWithStatusIndicator = withStatusIndicator(ScrapePoolContent);
 
-const ScrapePoolList: FC<{ filter: FilterData } & PathPrefixProps> = ({ pathPrefix, filter }) => {
-  const { response, error, isLoading } = useFetch<ScrapePoolListProps>(`${pathPrefix}/api/v1/targets?state=active`);
+const ScrapePoolList: FC<{ filter: FilterData }> = ({ filter }) => {
+  const pathPrefix = usePathPrefix();
+  const { response, error, isLoading } = useFetch<ScrapePoolListProps>(`${pathPrefix}/${API_PATH}/targets?state=active`);
   const { status: responseStatus } = response;
   const badResponse = responseStatus !== 'success' && responseStatus !== 'start fetching';
   return (
diff --git a/web/ui/react-app/src/pages/targets/Targets.test.tsx b/web/ui/react-app/src/pages/targets/Targets.test.tsx
index 866c35b095..198ab40a39 100644
--- a/web/ui/react-app/src/pages/targets/Targets.test.tsx
+++ b/web/ui/react-app/src/pages/targets/Targets.test.tsx
@@ -28,6 +28,5 @@ describe('Targets', () => {
     const scrapePoolList = targets.find(ScrapePoolList);
     expect(scrapePoolList).toHaveLength(1);
     expect(scrapePoolList.prop('filter')).toEqual({ showHealthy: true, showUnhealthy: true });
-    expect(scrapePoolList.prop('pathPrefix')).toEqual(defaultProps.pathPrefix);
   });
 });
diff --git a/web/ui/react-app/src/pages/targets/Targets.tsx b/web/ui/react-app/src/pages/targets/Targets.tsx
index 5f4737196e..99314d47c1 100644
--- a/web/ui/react-app/src/pages/targets/Targets.tsx
+++ b/web/ui/react-app/src/pages/targets/Targets.tsx
@@ -2,13 +2,15 @@ import React, { FC } from 'react';
 import { RouteComponentProps } from '@reach/router';
 import Filter from './Filter';
 import ScrapePoolList from './ScrapePoolList';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { useLocalStorage } from '../../hooks/useLocalStorage';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
-const Targets: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix }) => {
+const Targets: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
   const [filter, setFilter] = useLocalStorage('targets-page-filter', { showHealthy: true, showUnhealthy: true });
   const filterProps = { filter, setFilter };
-  const scrapePoolListProps = { filter, pathPrefix };
+  const scrapePoolListProps = { filter, pathPrefix, API_PATH };
 
   return (
     <>
diff --git a/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.test.tsx b/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.test.tsx
index 56ecb2f2b8..e7467c3eca 100644
--- a/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.test.tsx
+++ b/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.test.tsx
@@ -5,6 +5,7 @@ import { Table } from 'reactstrap';
 
 import TSDBStatus from './TSDBStatus';
 import { TSDBMap } from './TSDBStatus';
+import { PathPrefixContext } from '../../contexts/PathPrefixContext';
 
 const fakeTSDBStatusResponse: {
   status: string;
@@ -66,11 +67,15 @@ describe('TSDB Stats', () => {
       const mock = fetchMock.mockResponse(JSON.stringify(fakeTSDBStatusResponse));
       let page: any;
       await act(async () => {
-        page = mount(<TSDBStatus pathPrefix="/path/prefix" />);
+        page = mount(
+          <PathPrefixContext.Provider value="/path/prefix">
+            <TSDBStatus />
+          </PathPrefixContext.Provider>
+        );
       });
       page.update();
 
-      expect(mock).toHaveBeenCalledWith('/path/prefix/api/v1/status/tsdb', {
+      expect(mock).toHaveBeenCalledWith('/path/prefix/../api/v1/status/tsdb', {
         cache: 'no-store',
         credentials: 'same-origin',
       });
diff --git a/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.tsx b/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.tsx
index ff329148b1..d5539ccf7b 100644
--- a/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.tsx
+++ b/web/ui/react-app/src/pages/tsdbStatus/TSDBStatus.tsx
@@ -3,8 +3,9 @@ import { RouteComponentProps } from '@reach/router';
 import { Table } from 'reactstrap';
 
 import { useFetch } from '../../hooks/useFetch';
-import PathPrefixProps from '../../types/PathPrefixProps';
 import { withStatusIndicator } from '../../components/withStatusIndicator';
+import { usePathPrefix } from '../../contexts/PathPrefixContext';
+import { API_PATH } from '../../constants/constants';
 
 interface Stats {
   name: string;
@@ -101,8 +102,9 @@ TSDBStatusContent.displayName = 'TSDBStatusContent';
 
 const TSDBStatusContentWithStatusIndicator = withStatusIndicator(TSDBStatusContent);
 
-const TSDBStatus: FC<RouteComponentProps & PathPrefixProps> = ({ pathPrefix }) => {
-  const { response, error, isLoading } = useFetch<TSDBMap>(`${pathPrefix}/api/v1/status/tsdb`);
+const TSDBStatus: FC<RouteComponentProps> = () => {
+  const pathPrefix = usePathPrefix();
+  const { response, error, isLoading } = useFetch<TSDBMap>(`${pathPrefix}/${API_PATH}/status/tsdb`);
 
   return (
     <TSDBStatusContentWithStatusIndicator
diff --git a/web/ui/react-app/src/types/PathPrefixProps.ts b/web/ui/react-app/src/types/PathPrefixProps.ts
deleted file mode 100644
index 34bf6d5396..0000000000
--- a/web/ui/react-app/src/types/PathPrefixProps.ts
+++ /dev/null
@@ -1,5 +0,0 @@
-interface PathPrefixProps {
-  pathPrefix?: string;
-}
-
-export default PathPrefixProps;
diff --git a/web/web.go b/web/web.go
index 51ab23ad35..df18c2641a 100644
--- a/web/web.go
+++ b/web/web.go
@@ -79,7 +79,6 @@ var reactRouterPaths = []string{
 	"/status",
 	"/targets",
 	"/tsdb-status",
-	"/version",
 }
 
 // withStackTrace logs the stack trace in case the request panics. The function
@@ -393,8 +392,7 @@ func New(logger log.Logger, o *Options) *Handler {
 				fmt.Fprintf(w, "Error reading React index.html: %v", err)
 				return
 			}
-			replacedIdx := bytes.ReplaceAll(idx, []byte("PATH_PREFIX_PLACEHOLDER"), []byte(o.ExternalURL.Path))
-			replacedIdx = bytes.ReplaceAll(replacedIdx, []byte("CONSOLES_LINK_PLACEHOLDER"), []byte(h.consolesPath()))
+			replacedIdx := bytes.ReplaceAll(idx, []byte("CONSOLES_LINK_PLACEHOLDER"), []byte(h.consolesPath()))
 			replacedIdx = bytes.ReplaceAll(replacedIdx, []byte("TITLE_PLACEHOLDER"), []byte(h.options.PageTitle))
 			w.Write(replacedIdx)
 			return