diff --git a/cmd/prometheus/main.go b/cmd/prometheus/main.go
index e7fd82e6f..7d9106b33 100644
--- a/cmd/prometheus/main.go
+++ b/cmd/prometheus/main.go
@@ -1597,6 +1597,10 @@ func (n notReadyAppender) AppendHistogram(ref storage.SeriesRef, l labels.Labels
 	return 0, tsdb.ErrNotReady
 }
 
+func (n notReadyAppender) AppendHistogramCTZeroSample(ref storage.SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	return 0, tsdb.ErrNotReady
+}
+
 func (n notReadyAppender) UpdateMetadata(ref storage.SeriesRef, l labels.Labels, m metadata.Metadata) (storage.SeriesRef, error) {
 	return 0, tsdb.ErrNotReady
 }
diff --git a/scrape/helpers_test.go b/scrape/helpers_test.go
index 116fa5c94..4f7918f79 100644
--- a/scrape/helpers_test.go
+++ b/scrape/helpers_test.go
@@ -55,6 +55,10 @@ func (a nopAppender) AppendHistogram(storage.SeriesRef, labels.Labels, int64, *h
 	return 0, nil
 }
 
+func (a nopAppender) AppendHistogramCTZeroSample(ref storage.SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	return 0, nil
+}
+
 func (a nopAppender) UpdateMetadata(storage.SeriesRef, labels.Labels, metadata.Metadata) (storage.SeriesRef, error) {
 	return 0, nil
 }
@@ -78,9 +82,10 @@ func equalFloatSamples(a, b floatSample) bool {
 }
 
 type histogramSample struct {
-	t  int64
-	h  *histogram.Histogram
-	fh *histogram.FloatHistogram
+	metric labels.Labels
+	t      int64
+	h      *histogram.Histogram
+	fh     *histogram.FloatHistogram
 }
 
 type collectResultAppendable struct {
@@ -146,7 +151,7 @@ func (a *collectResultAppender) AppendExemplar(ref storage.SeriesRef, l labels.L
 func (a *collectResultAppender) AppendHistogram(ref storage.SeriesRef, l labels.Labels, t int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
 	a.mtx.Lock()
 	defer a.mtx.Unlock()
-	a.pendingHistograms = append(a.pendingHistograms, histogramSample{h: h, fh: fh, t: t})
+	a.pendingHistograms = append(a.pendingHistograms, histogramSample{h: h, fh: fh, t: t, metric: l})
 	if a.next == nil {
 		return 0, nil
 	}
@@ -154,6 +159,13 @@ func (a *collectResultAppender) AppendHistogram(ref storage.SeriesRef, l labels.
 	return a.next.AppendHistogram(ref, l, t, h, fh)
 }
 
+func (a *collectResultAppender) AppendHistogramCTZeroSample(ref storage.SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	if h != nil {
+		return a.AppendHistogram(ref, l, ct, &histogram.Histogram{}, nil)
+	}
+	return a.AppendHistogram(ref, l, ct, nil, &histogram.FloatHistogram{})
+}
+
 func (a *collectResultAppender) UpdateMetadata(ref storage.SeriesRef, l labels.Labels, m metadata.Metadata) (storage.SeriesRef, error) {
 	a.mtx.Lock()
 	defer a.mtx.Unlock()
diff --git a/scrape/manager_test.go b/scrape/manager_test.go
index cd712ca62..13a369812 100644
--- a/scrape/manager_test.go
+++ b/scrape/manager_test.go
@@ -39,8 +39,10 @@ import (
 	"github.com/prometheus/prometheus/discovery"
 	_ "github.com/prometheus/prometheus/discovery/file"
 	"github.com/prometheus/prometheus/discovery/targetgroup"
+	"github.com/prometheus/prometheus/model/histogram"
 	"github.com/prometheus/prometheus/model/labels"
 	"github.com/prometheus/prometheus/model/relabel"
+	"github.com/prometheus/prometheus/tsdb/tsdbutil"
 	"github.com/prometheus/prometheus/util/runutil"
 	"github.com/prometheus/prometheus/util/testutil"
 )
@@ -858,6 +860,178 @@ func TestManagerCTZeroIngestion(t *testing.T) {
 	}
 }
 
+// generateTestHistogram generates the same thing as tsdbutil.GenerateTestHistogram,
+// but in the form of dto.Histogram.
+func generateTestHistogram(i int) *dto.Histogram {
+	helper := tsdbutil.GenerateTestHistogram(i)
+	h := &dto.Histogram{}
+	h.SampleCount = proto.Uint64(helper.Count)
+	h.SampleSum = proto.Float64(helper.Sum)
+	h.Schema = proto.Int32(helper.Schema)
+	h.ZeroThreshold = proto.Float64(helper.ZeroThreshold)
+	h.ZeroCount = proto.Uint64(helper.ZeroCount)
+	h.PositiveSpan = make([]*dto.BucketSpan, len(helper.PositiveSpans))
+	for i, span := range helper.PositiveSpans {
+		h.PositiveSpan[i] = &dto.BucketSpan{
+			Offset: proto.Int32(span.Offset),
+			Length: proto.Uint32(span.Length),
+		}
+	}
+	h.PositiveDelta = helper.PositiveBuckets
+	h.NegativeSpan = make([]*dto.BucketSpan, len(helper.NegativeSpans))
+	for i, span := range helper.NegativeSpans {
+		h.NegativeSpan[i] = &dto.BucketSpan{
+			Offset: proto.Int32(span.Offset),
+			Length: proto.Uint32(span.Length),
+		}
+	}
+	h.NegativeDelta = helper.NegativeBuckets
+	return h
+}
+
+func TestManagerCTZeroIngestionHistogram(t *testing.T) {
+	const mName = "expected_histogram"
+
+	for _, tc := range []struct {
+		name                  string
+		inputHistSample       *dto.Histogram
+		enableCTZeroIngestion bool
+	}{
+		{
+			name: "disabled with CT on histogram",
+			inputHistSample: func() *dto.Histogram {
+				h := generateTestHistogram(0)
+				h.CreatedTimestamp = timestamppb.Now()
+				return h
+			}(),
+			enableCTZeroIngestion: false,
+		},
+		{
+			name: "enabled with CT on histogram",
+			inputHistSample: func() *dto.Histogram {
+				h := generateTestHistogram(0)
+				h.CreatedTimestamp = timestamppb.Now()
+				return h
+			}(),
+			enableCTZeroIngestion: true,
+		},
+		{
+			name: "enabled without CT on histogram",
+			inputHistSample: func() *dto.Histogram {
+				h := generateTestHistogram(0)
+				return h
+			}(),
+			enableCTZeroIngestion: true,
+		},
+	} {
+		t.Run(tc.name, func(t *testing.T) {
+			app := &collectResultAppender{}
+			scrapeManager, err := NewManager(
+				&Options{
+					EnableCreatedTimestampZeroIngestion: tc.enableCTZeroIngestion,
+					EnableNativeHistogramsIngestion:     true,
+					skipOffsetting:                      true,
+				},
+				log.NewLogfmtLogger(os.Stderr),
+				nil,
+				&collectResultAppendable{app},
+				prometheus.NewRegistry(),
+			)
+			require.NoError(t, err)
+
+			require.NoError(t, scrapeManager.ApplyConfig(&config.Config{
+				GlobalConfig: config.GlobalConfig{
+					// Disable regular scrapes.
+					ScrapeInterval: model.Duration(9999 * time.Minute),
+					ScrapeTimeout:  model.Duration(5 * time.Second),
+					// Ensure the proto is chosen. We need proto as it's the only protocol
+					// with the CT parsing support.
+					ScrapeProtocols: []config.ScrapeProtocol{config.PrometheusProto},
+				},
+				ScrapeConfigs: []*config.ScrapeConfig{{JobName: "test"}},
+			}))
+
+			once := sync.Once{}
+			// Start fake HTTP target to that allow one scrape only.
+			server := httptest.NewServer(
+				http.HandlerFunc(func(w http.ResponseWriter, r *http.Request) {
+					fail := true // TODO(bwplotka): Kill or use?
+					once.Do(func() {
+						fail = false
+						w.Header().Set("Content-Type", `application/vnd.google.protobuf; proto=io.prometheus.client.MetricFamily; encoding=delimited`)
+
+						ctrType := dto.MetricType_HISTOGRAM
+						w.Write(protoMarshalDelimited(t, &dto.MetricFamily{
+							Name:   proto.String(mName),
+							Type:   &ctrType,
+							Metric: []*dto.Metric{{Histogram: tc.inputHistSample}},
+						}))
+					})
+
+					if fail {
+						w.WriteHeader(http.StatusInternalServerError)
+					}
+				}),
+			)
+			defer server.Close()
+
+			serverURL, err := url.Parse(server.URL)
+			require.NoError(t, err)
+
+			// Add fake target directly into tsets + reload. Normally users would use
+			// Manager.Run and wait for minimum 5s refresh interval.
+			scrapeManager.updateTsets(map[string][]*targetgroup.Group{
+				"test": {{
+					Targets: []model.LabelSet{{
+						model.SchemeLabel:  model.LabelValue(serverURL.Scheme),
+						model.AddressLabel: model.LabelValue(serverURL.Host),
+					}},
+				}},
+			})
+			scrapeManager.reload()
+
+			var got []histogramSample
+
+			// Wait for one scrape.
+			ctx, cancel := context.WithTimeout(context.Background(), 1*time.Minute)
+			defer cancel()
+			require.NoError(t, runutil.Retry(100*time.Millisecond, ctx.Done(), func() error {
+				app.mtx.Lock()
+				defer app.mtx.Unlock()
+
+				// Check if scrape happened and grab the relevant histograms, they have to be there - or it's a bug
+				// and it's not worth waiting.
+				for _, h := range app.resultHistograms {
+					if h.metric.Get(model.MetricNameLabel) == mName {
+						got = append(got, h)
+					}
+				}
+				if len(app.resultHistograms) > 0 {
+					return nil
+				}
+				return fmt.Errorf("expected some histogram samples, got none")
+			}), "after 1 minute")
+			scrapeManager.Stop()
+
+			// Check for zero samples, assuming we only injected always one histogram sample.
+			// Did it contain CT to inject? If yes, was CT zero enabled?
+			if tc.inputHistSample.CreatedTimestamp.IsValid() && tc.enableCTZeroIngestion {
+				require.Len(t, got, 2)
+				// Zero sample.
+				require.Equal(t, histogram.Histogram{}, *got[0].h)
+				// Quick soft check to make sure it's the same sample or at least not zero.
+				require.Equal(t, tc.inputHistSample.GetSampleSum(), got[1].h.Sum)
+				return
+			}
+
+			// Expect only one, valid sample.
+			require.Len(t, got, 1)
+			// Quick soft check to make sure it's the same sample or at least not zero.
+			require.Equal(t, tc.inputHistSample.GetSampleSum(), got[0].h.Sum)
+		})
+	}
+}
+
 func TestUnregisterMetrics(t *testing.T) {
 	reg := prometheus.NewRegistry()
 	// Check that all metrics can be unregistered, allowing a second manager to be created.
diff --git a/scrape/scrape.go b/scrape/scrape.go
index dca4682b1..f29beeb03 100644
--- a/scrape/scrape.go
+++ b/scrape/scrape.go
@@ -1701,7 +1701,15 @@ loop:
 		} else {
 			if sl.enableCTZeroIngestion {
 				if ctMs := p.CreatedTimestamp(); ctMs != nil {
-					ref, err = app.AppendCTZeroSample(ref, lset, t, *ctMs)
+					if isHistogram && sl.enableNativeHistogramIngestion {
+						if h != nil {
+							ref, err = app.AppendHistogramCTZeroSample(ref, lset, t, *ctMs, h, nil)
+						} else {
+							ref, err = app.AppendHistogramCTZeroSample(ref, lset, t, *ctMs, nil, fh)
+						}
+					} else {
+						ref, err = app.AppendCTZeroSample(ref, lset, t, *ctMs)
+					}
 					if err != nil && !errors.Is(err, storage.ErrOutOfOrderCT) { // OOO is a common case, ignoring completely for now.
 						// CT is an experimental feature. For now, we don't need to fail the
 						// scrape on errors updating the created timestamp, log debug.
diff --git a/scrape/scrape_test.go b/scrape/scrape_test.go
index 9887924c3..9e49fe8ef 100644
--- a/scrape/scrape_test.go
+++ b/scrape/scrape_test.go
@@ -1999,7 +1999,8 @@ metric: <
 `,
 			contentType: "application/vnd.google.protobuf",
 			histograms: []histogramSample{{
-				t: 1234568,
+				t:      1234568,
+				metric: labels.FromStrings("__name__", "test_histogram"),
 				h: &histogram.Histogram{
 					Count:         175,
 					ZeroCount:     2,
@@ -2125,7 +2126,8 @@ metric: <
 				{metric: labels.FromStrings("__name__", "test_histogram_bucket", "le", "+Inf"), t: 1234568, f: 175},
 			},
 			histograms: []histogramSample{{
-				t: 1234568,
+				t:      1234568,
+				metric: labels.FromStrings("__name__", "test_histogram"),
 				h: &histogram.Histogram{
 					Count:         175,
 					ZeroCount:     2,
diff --git a/storage/fanout.go b/storage/fanout.go
index e52342bc7..80022b256 100644
--- a/storage/fanout.go
+++ b/storage/fanout.go
@@ -190,6 +190,20 @@ func (f *fanoutAppender) AppendHistogram(ref SeriesRef, l labels.Labels, t int64
 	return ref, nil
 }
 
+func (f *fanoutAppender) AppendHistogramCTZeroSample(ref SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (SeriesRef, error) {
+	ref, err := f.primary.AppendHistogramCTZeroSample(ref, l, t, ct, h, fh)
+	if err != nil {
+		return ref, err
+	}
+
+	for _, appender := range f.secondaries {
+		if _, err := appender.AppendHistogramCTZeroSample(ref, l, t, ct, h, fh); err != nil {
+			return 0, err
+		}
+	}
+	return ref, nil
+}
+
 func (f *fanoutAppender) UpdateMetadata(ref SeriesRef, l labels.Labels, m metadata.Metadata) (SeriesRef, error) {
 	ref, err := f.primary.UpdateMetadata(ref, l, m)
 	if err != nil {
diff --git a/storage/interface.go b/storage/interface.go
index 9654c8833..7ac93129e 100644
--- a/storage/interface.go
+++ b/storage/interface.go
@@ -50,7 +50,8 @@ var (
 	// NOTE(bwplotka): This can be both an instrumentation failure or commonly expected
 	// behaviour, and we currently don't have a way to determine this. As a result
 	// it's recommended to ignore this error for now.
-	ErrOutOfOrderCT = fmt.Errorf("created timestamp out of order, ignoring")
+	ErrOutOfOrderCT      = fmt.Errorf("created timestamp out of order, ignoring")
+	ErrCTNewerThanSample = fmt.Errorf("CT is newer or the same as sample's timestamp, ignoring")
 )
 
 // SeriesRef is a generic series reference. In prometheus it is either a
@@ -313,6 +314,20 @@ type HistogramAppender interface {
 	// pointer. AppendHistogram won't mutate the histogram, but in turn
 	// depends on the caller to not mutate it either.
 	AppendHistogram(ref SeriesRef, l labels.Labels, t int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (SeriesRef, error)
+	// AppendHistogramCTZeroSample adds synthetic zero sample for the given ct timestamp,
+	// which will be associated with given series, labels and the incoming
+	// sample's t (timestamp). AppendHistogramCTZeroSample returns error if zero sample can't be
+	// appended, for example when ct is too old, or when it would collide with
+	// incoming sample (sample has priority).
+	//
+	// AppendHistogramCTZeroSample has to be called before the corresponding histogram AppendHistogram.
+	// A series reference number is returned which can be used to modify the
+	// CT for the given series in the same or later transactions.
+	// Returned reference numbers are ephemeral and may be rejected in calls
+	// to AppendHistogramCTZeroSample() at any point.
+	//
+	// If the reference is 0 it must not be used for caching.
+	AppendHistogramCTZeroSample(ref SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (SeriesRef, error)
 }
 
 // MetadataUpdater provides an interface for associating metadata to stored series.
diff --git a/storage/remote/write.go b/storage/remote/write.go
index eba429084..624732c4f 100644
--- a/storage/remote/write.go
+++ b/storage/remote/write.go
@@ -306,6 +306,11 @@ func (t *timestampTracker) AppendHistogram(_ storage.SeriesRef, _ labels.Labels,
 	return 0, nil
 }
 
+func (t *timestampTracker) AppendHistogramCTZeroSample(_ storage.SeriesRef, _ labels.Labels, _, _ int64, _ *histogram.Histogram, _ *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	// TODO: Implement
+	return 0, nil
+}
+
 func (t *timestampTracker) UpdateMetadata(_ storage.SeriesRef, _ labels.Labels, _ metadata.Metadata) (storage.SeriesRef, error) {
 	// TODO: Add and increment a `metadata` field when we get around to wiring metadata in remote_write.
 	// UpdateMetadata is no-op for remote write (where timestampTracker is being used) for now.
diff --git a/storage/remote/write_handler_test.go b/storage/remote/write_handler_test.go
index 5c89a1ab9..8e628f40d 100644
--- a/storage/remote/write_handler_test.go
+++ b/storage/remote/write_handler_test.go
@@ -915,6 +915,13 @@ func (m *mockAppendable) AppendHistogram(_ storage.SeriesRef, l labels.Labels, t
 	return 0, nil
 }
 
+func (m *mockAppendable) AppendHistogramCTZeroSample(ref storage.SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	// AppendCTZeroSample is no-op for remote-write for now.
+	// TODO(bwplotka/arthursens): Add support for PRW 2.0 for CT zero feature (but also we might
+	// replace this with in-metadata CT storage, see https://github.com/prometheus/prometheus/issues/14218).
+	return 0, nil
+}
+
 func (m *mockAppendable) UpdateMetadata(_ storage.SeriesRef, l labels.Labels, mp metadata.Metadata) (storage.SeriesRef, error) {
 	if m.updateMetadataErr != nil {
 		return 0, m.updateMetadataErr
diff --git a/tsdb/agent/db.go b/tsdb/agent/db.go
index 596d5c8a3..5e33fce80 100644
--- a/tsdb/agent/db.go
+++ b/tsdb/agent/db.go
@@ -972,6 +972,11 @@ func (a *appender) AppendHistogram(ref storage.SeriesRef, l labels.Labels, t int
 	return storage.SeriesRef(series.ref), nil
 }
 
+func (a *appender) AppendHistogramCTZeroSample(ref storage.SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	// TODO(bwplotka/arthursens): Wire metadata in the Agent's appender.
+	return 0, nil
+}
+
 func (a *appender) UpdateMetadata(storage.SeriesRef, labels.Labels, metadata.Metadata) (storage.SeriesRef, error) {
 	// TODO: Wire metadata in the Agent's appender.
 	return 0, nil
diff --git a/tsdb/head_append.go b/tsdb/head_append.go
index 3dd9a367b..10fb17809 100644
--- a/tsdb/head_append.go
+++ b/tsdb/head_append.go
@@ -79,6 +79,16 @@ func (a *initAppender) AppendHistogram(ref storage.SeriesRef, l labels.Labels, t
 	return a.app.AppendHistogram(ref, l, t, h, fh)
 }
 
+func (a *initAppender) AppendHistogramCTZeroSample(ref storage.SeriesRef, l labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	if a.app != nil {
+		return a.app.AppendHistogramCTZeroSample(ref, l, t, ct, h, fh)
+	}
+	a.head.initTime(t)
+	a.app = a.head.appender()
+
+	return a.app.AppendHistogramCTZeroSample(ref, l, t, ct, h, fh)
+}
+
 func (a *initAppender) UpdateMetadata(ref storage.SeriesRef, l labels.Labels, m metadata.Metadata) (storage.SeriesRef, error) {
 	if a.app != nil {
 		return a.app.UpdateMetadata(ref, l, m)
@@ -388,7 +398,7 @@ func (a *headAppender) Append(ref storage.SeriesRef, lset labels.Labels, t int64
 // storage.CreatedTimestampAppender.AppendCTZeroSample for further documentation.
 func (a *headAppender) AppendCTZeroSample(ref storage.SeriesRef, lset labels.Labels, t, ct int64) (storage.SeriesRef, error) {
 	if ct >= t {
-		return 0, fmt.Errorf("CT is newer or the same as sample's timestamp, ignoring")
+		return 0, storage.ErrCTNewerThanSample
 	}
 
 	s := a.head.series.getByID(chunks.HeadSeriesRef(ref))
@@ -747,6 +757,107 @@ func (a *headAppender) AppendHistogram(ref storage.SeriesRef, lset labels.Labels
 	return storage.SeriesRef(s.ref), nil
 }
 
+func (a *headAppender) AppendHistogramCTZeroSample(ref storage.SeriesRef, lset labels.Labels, t, ct int64, h *histogram.Histogram, fh *histogram.FloatHistogram) (storage.SeriesRef, error) {
+	if !a.head.opts.EnableNativeHistograms.Load() {
+		return 0, storage.ErrNativeHistogramsDisabled
+	}
+
+	if ct >= t {
+		return 0, storage.ErrCTNewerThanSample
+	}
+	s := a.head.series.getByID(chunks.HeadSeriesRef(ref))
+	if s == nil {
+		// Ensure no empty labels have gotten through.
+		lset = lset.WithoutEmpty()
+		if lset.IsEmpty() {
+			return 0, fmt.Errorf("empty labelset: %w", ErrInvalidSample)
+		}
+
+		if l, dup := lset.HasDuplicateLabelNames(); dup {
+			return 0, fmt.Errorf(`label name "%s" is not unique: %w`, l, ErrInvalidSample)
+		}
+
+		var created bool
+		var err error
+		s, created, err = a.head.getOrCreate(lset.Hash(), lset)
+		if err != nil {
+			return 0, err
+		}
+		if created {
+			switch {
+			case h != nil:
+				s.lastHistogramValue = &histogram.Histogram{}
+			case fh != nil:
+				s.lastFloatHistogramValue = &histogram.FloatHistogram{}
+			}
+			a.series = append(a.series, record.RefSeries{
+				Ref:    s.ref,
+				Labels: lset,
+			})
+		}
+	}
+
+	switch {
+	case h != nil:
+		zeroHistogram := &histogram.Histogram{}
+		s.Lock()
+		// Although we call `appendableHistogram` with oooHistogramsEnabled=true, for CTZeroSamples OOO is not allowed.
+		// We set it to true to make this implementation as close as possible to the float implementation.
+		isOOO, _, err := s.appendableHistogram(ct, zeroHistogram, a.headMaxt, a.minValidTime, a.oooTimeWindow, true)
+		if err != nil {
+			s.Unlock()
+			if errors.Is(err, storage.ErrOutOfOrderSample) {
+				return 0, storage.ErrOutOfOrderCT
+			}
+		}
+		// OOO is not allowed because after the first scrape, CT will be the same for most (if not all) future samples.
+		// This is to prevent the injected zero from being marked as OOO forever.
+		if isOOO {
+			s.Unlock()
+			return 0, storage.ErrOutOfOrderCT
+		}
+		s.pendingCommit = true
+		s.Unlock()
+		a.histograms = append(a.histograms, record.RefHistogramSample{
+			Ref: s.ref,
+			T:   ct,
+			H:   zeroHistogram,
+		})
+		a.histogramSeries = append(a.histogramSeries, s)
+	case fh != nil:
+		zeroFloatHistogram := &histogram.FloatHistogram{}
+		s.Lock()
+		// Although we call `appendableFloatHistogram` with oooHistogramsEnabled=true, for CTZeroSamples OOO is not allowed.
+		// We set it to true to make this implementation as close as possible to the float implementation.
+		isOOO, _, err := s.appendableFloatHistogram(ct, zeroFloatHistogram, a.headMaxt, a.minValidTime, a.oooTimeWindow, true) // OOO is not allowed for CTZeroSamples.
+		if err != nil {
+			s.Unlock()
+			if errors.Is(err, storage.ErrOutOfOrderSample) {
+				return 0, storage.ErrOutOfOrderCT
+			}
+		}
+		// OOO is not allowed because after the first scrape, CT will be the same for most (if not all) future samples.
+		// This is to prevent the injected zero from being marked as OOO forever.
+		if isOOO {
+			s.Unlock()
+			return 0, storage.ErrOutOfOrderCT
+		}
+		s.pendingCommit = true
+		s.Unlock()
+		a.floatHistograms = append(a.floatHistograms, record.RefFloatHistogramSample{
+			Ref: s.ref,
+			T:   ct,
+			FH:  zeroFloatHistogram,
+		})
+		a.floatHistogramSeries = append(a.floatHistogramSeries, s)
+	}
+
+	if ct > a.maxt {
+		a.maxt = ct
+	}
+	return storage.SeriesRef(s.ref), nil
+}
+
 // UpdateMetadata for headAppender assumes the series ref already exists, and so it doesn't
 // use getOrCreate or make any of the lset sanity checks that Append does.
 func (a *headAppender) UpdateMetadata(ref storage.SeriesRef, lset labels.Labels, meta metadata.Metadata) (storage.SeriesRef, error) {
diff --git a/tsdb/head_test.go b/tsdb/head_test.go
index 483121dc6..ebfd1ff8b 100644
--- a/tsdb/head_test.go
+++ b/tsdb/head_test.go
@@ -6363,6 +6363,166 @@ func TestHeadAppender_AppendCTZeroSample(t *testing.T) {
 	}
 }
 
+func TestHeadAppender_AppendHistogramCTZeroSample(t *testing.T) {
+	testHistogram := tsdbutil.GenerateTestHistogram(1)
+	testFloatHistogram := tsdbutil.GenerateTestFloatHistogram(1)
+	lbls := labels.FromStrings("foo", "bar")
+	type appendableHistograms struct {
+		ts int64
+		h  *histogram.Histogram
+		fh *histogram.FloatHistogram
+		ct int64
+	}
+	for _, tc := range []struct {
+		name                 string
+		appendableHistograms []appendableHistograms
+		expectedHistograms   []chunks.Sample
+	}{
+		{
+			name: "In order ct+normal sample/histogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, h: testHistogram, ct: 1},
+				{ts: 101, h: testHistogram, ct: 1},
+			},
+			expectedHistograms: func() []chunks.Sample {
+				hNoCounterReset := *testHistogram
+				hNoCounterReset.CounterResetHint = histogram.NotCounterReset
+				return []chunks.Sample{
+					sample{t: 1, h: &histogram.Histogram{}},
+					sample{t: 100, h: testHistogram},
+					sample{t: 101, h: &hNoCounterReset},
+				}
+			}(),
+		},
+		{
+			name: "In order ct+normal sample/floathistogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, fh: testFloatHistogram, ct: 1},
+				{ts: 101, fh: testFloatHistogram, ct: 1},
+			},
+			expectedHistograms: func() []chunks.Sample {
+				fhNoCounterReset := *testFloatHistogram
+				fhNoCounterReset.CounterResetHint = histogram.NotCounterReset
+				return []chunks.Sample{
+					sample{t: 1, fh: &histogram.FloatHistogram{}},
+					sample{t: 100, fh: testFloatHistogram},
+					sample{t: 101, fh: &fhNoCounterReset},
+				}
+			}(),
+		},
+		{
+			name: "Consecutive appends with same ct ignore ct/histogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, h: testHistogram, ct: 1},
+				{ts: 101, h: testHistogram, ct: 1},
+			},
+			expectedHistograms: func() []chunks.Sample {
+				hNoCounterReset := *testHistogram
+				hNoCounterReset.CounterResetHint = histogram.NotCounterReset
+				return []chunks.Sample{
+					sample{t: 1, h: &histogram.Histogram{}},
+					sample{t: 100, h: testHistogram},
+					sample{t: 101, h: &hNoCounterReset},
+				}
+			}(),
+		},
+		{
+			name: "Consecutive appends with same ct ignore ct/floathistogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, fh: testFloatHistogram, ct: 1},
+				{ts: 101, fh: testFloatHistogram, ct: 1},
+			},
+			expectedHistograms: func() []chunks.Sample {
+				fhNoCounterReset := *testFloatHistogram
+				fhNoCounterReset.CounterResetHint = histogram.NotCounterReset
+				return []chunks.Sample{
+					sample{t: 1, fh: &histogram.FloatHistogram{}},
+					sample{t: 100, fh: testFloatHistogram},
+					sample{t: 101, fh: &fhNoCounterReset},
+				}
+			}(),
+		},
+		{
+			name: "Consecutive appends with newer ct do not ignore ct/histogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, h: testHistogram, ct: 1},
+				{ts: 102, h: testHistogram, ct: 101},
+			},
+			expectedHistograms: []chunks.Sample{
+				sample{t: 1, h: &histogram.Histogram{}},
+				sample{t: 100, h: testHistogram},
+				sample{t: 101, h: &histogram.Histogram{CounterResetHint: histogram.CounterReset}},
+				sample{t: 102, h: testHistogram},
+			},
+		},
+		{
+			name: "Consecutive appends with newer ct do not ignore ct/floathistogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, fh: testFloatHistogram, ct: 1},
+				{ts: 102, fh: testFloatHistogram, ct: 101},
+			},
+			expectedHistograms: []chunks.Sample{
+				sample{t: 1, fh: &histogram.FloatHistogram{}},
+				sample{t: 100, fh: testFloatHistogram},
+				sample{t: 101, fh: &histogram.FloatHistogram{CounterResetHint: histogram.CounterReset}},
+				sample{t: 102, fh: testFloatHistogram},
+			},
+		},
+		{
+			name: "CT equals to previous sample timestamp is ignored/histogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, h: testHistogram, ct: 1},
+				{ts: 101, h: testHistogram, ct: 100},
+			},
+			expectedHistograms: func() []chunks.Sample {
+				hNoCounterReset := *testHistogram
+				hNoCounterReset.CounterResetHint = histogram.NotCounterReset
+				return []chunks.Sample{
+					sample{t: 1, h: &histogram.Histogram{}},
+					sample{t: 100, h: testHistogram},
+					sample{t: 101, h: &hNoCounterReset},
+				}
+			}(),
+		},
+		{
+			name: "CT equals to previous sample timestamp is ignored/floathistogram",
+			appendableHistograms: []appendableHistograms{
+				{ts: 100, fh: testFloatHistogram, ct: 1},
+				{ts: 101, fh: testFloatHistogram, ct: 100},
+			},
+			expectedHistograms: func() []chunks.Sample {
+				fhNoCounterReset := *testFloatHistogram
+				fhNoCounterReset.CounterResetHint = histogram.NotCounterReset
+				return []chunks.Sample{
+					sample{t: 1, fh: &histogram.FloatHistogram{}},
+					sample{t: 100, fh: testFloatHistogram},
+					sample{t: 101, fh: &fhNoCounterReset},
+				}
+			}(),
+		},
+	} {
+		t.Run(tc.name, func(t *testing.T) {
+			head, _ := newTestHead(t, DefaultBlockDuration, wlog.CompressionNone, false)
+			defer func() {
+				require.NoError(t, head.Close())
+			}()
+			appender := head.Appender(context.Background())
+			for _, sample := range tc.appendableHistograms {
+				ref, err := appender.AppendHistogramCTZeroSample(0, lbls, sample.ts, sample.ct, sample.h, sample.fh)
+				require.NoError(t, err)
+				_, err = appender.AppendHistogram(ref, lbls, sample.ts, sample.h, sample.fh)
+				require.NoError(t, err)
+			}
+			require.NoError(t, appender.Commit())
+
+			q, err := NewBlockQuerier(head, math.MinInt64, math.MaxInt64)
+			require.NoError(t, err)
+			result := query(t, q, labels.MustNewMatcher(labels.MatchEqual, "foo", "bar"))
+			require.Equal(t, tc.expectedHistograms, result[`{foo="bar"}`])
+		})
+	}
+}
+
 func TestHeadCompactableDoesNotCompactEmptyHead(t *testing.T) {
 	// Use a chunk range of 1 here so that if we attempted to determine if the head
 	// was compactable using default values for min and max times, `Head.compactable()`