diff --git a/config/config.go b/config/config.go
index c924e3098..0880d518d 100644
--- a/config/config.go
+++ b/config/config.go
@@ -227,6 +227,9 @@ var (
 	DefaultExemplarsConfig = ExemplarsConfig{
 		MaxExemplars: 100000,
 	}
+
+	// DefaultOTLPConfig is the default OTLP configuration.
+	DefaultOTLPConfig = OTLPConfig{}
 )
 
 // Config is the top-level configuration for Prometheus's config files.
@@ -242,6 +245,7 @@ type Config struct {
 
 	RemoteWriteConfigs []*RemoteWriteConfig `yaml:"remote_write,omitempty"`
 	RemoteReadConfigs  []*RemoteReadConfig  `yaml:"remote_read,omitempty"`
+	OTLPConfig         OTLPConfig           `yaml:"otlp,omitempty"`
 }
 
 // SetDirectory joins any relative file paths with dir.
@@ -1304,3 +1308,15 @@ func getGoGCEnv() int {
 	}
 	return DefaultRuntimeConfig.GoGC
 }
+
+// OTLPConfig is the configuration for writing to the OTLP endpoint.
+type OTLPConfig struct {
+	PromoteResourceAttributes []string `yaml:"promote_resource_attributes,omitempty"`
+}
+
+// UnmarshalYAML implements the yaml.Unmarshaler interface.
+func (c *OTLPConfig) UnmarshalYAML(unmarshal func(interface{}) error) error {
+	*c = DefaultOTLPConfig
+	type plain OTLPConfig
+	return unmarshal((*plain)(c))
+}
diff --git a/docs/configuration/configuration.md b/docs/configuration/configuration.md
index 35976871b..5675210b7 100644
--- a/docs/configuration/configuration.md
+++ b/docs/configuration/configuration.md
@@ -152,6 +152,10 @@ alerting:
 remote_write:
   [ - <remote_write> ... ]
 
+# Settings related to the OTLP receiver feature.
+otlp:
+  [ promote_resource_attributes: [<string>, ...] | default = [ ] ]
+
 # Settings related to the remote read feature.
 remote_read:
   [ - <remote_read> ... ]
diff --git a/storage/remote/otlptranslator/prometheusremotewrite/helper.go b/storage/remote/otlptranslator/prometheusremotewrite/helper.go
index 257133853..f2d7ecd4e 100644
--- a/storage/remote/otlptranslator/prometheusremotewrite/helper.go
+++ b/storage/remote/otlptranslator/prometheusremotewrite/helper.go
@@ -65,14 +65,14 @@ type bucketBoundsData struct {
 	bound float64
 }
 
-// byBucketBoundsData enables the usage of sort.Sort() with a slice of bucket bounds
+// byBucketBoundsData enables the usage of sort.Sort() with a slice of bucket bounds.
 type byBucketBoundsData []bucketBoundsData
 
 func (m byBucketBoundsData) Len() int           { return len(m) }
 func (m byBucketBoundsData) Less(i, j int) bool { return m[i].bound < m[j].bound }
 func (m byBucketBoundsData) Swap(i, j int)      { m[i], m[j] = m[j], m[i] }
 
-// ByLabelName enables the usage of sort.Sort() with a slice of labels
+// ByLabelName enables the usage of sort.Sort() with a slice of labels.
 type ByLabelName []prompb.Label
 
 func (a ByLabelName) Len() int           { return len(a) }
@@ -115,14 +115,23 @@ var seps = []byte{'\xff'}
 // createAttributes creates a slice of Prometheus Labels with OTLP attributes and pairs of string values.
 // Unpaired string values are ignored. String pairs overwrite OTLP labels if collisions happen and
 // if logOnOverwrite is true, the overwrite is logged. Resulting label names are sanitized.
-func createAttributes(resource pcommon.Resource, attributes pcommon.Map, externalLabels map[string]string,
+// If settings.PromoteResourceAttributes is not empty, it's a set of resource attributes that should be promoted to labels.
+func createAttributes(resource pcommon.Resource, attributes pcommon.Map, settings Settings,
 	ignoreAttrs []string, logOnOverwrite bool, extras ...string) []prompb.Label {
 	resourceAttrs := resource.Attributes()
 	serviceName, haveServiceName := resourceAttrs.Get(conventions.AttributeServiceName)
 	instance, haveInstanceID := resourceAttrs.Get(conventions.AttributeServiceInstanceID)
 
+	promotedAttrs := make([]prompb.Label, 0, len(settings.PromoteResourceAttributes))
+	for _, name := range settings.PromoteResourceAttributes {
+		if value, exists := resourceAttrs.Get(name); exists {
+			promotedAttrs = append(promotedAttrs, prompb.Label{Name: name, Value: value.AsString()})
+		}
+	}
+	sort.Stable(ByLabelName(promotedAttrs))
+
 	// Calculate the maximum possible number of labels we could return so we can preallocate l
-	maxLabelCount := attributes.Len() + len(externalLabels) + len(extras)/2
+	maxLabelCount := attributes.Len() + len(settings.ExternalLabels) + len(promotedAttrs) + len(extras)/2
 
 	if haveServiceName {
 		maxLabelCount++
@@ -132,9 +141,6 @@ func createAttributes(resource pcommon.Resource, attributes pcommon.Map, externa
 		maxLabelCount++
 	}
 
-	// map ensures no duplicate label name
-	l := make(map[string]string, maxLabelCount)
-
 	// Ensure attributes are sorted by key for consistent merging of keys which
 	// collide when sanitized.
 	labels := make([]prompb.Label, 0, maxLabelCount)
@@ -148,6 +154,8 @@ func createAttributes(resource pcommon.Resource, attributes pcommon.Map, externa
 	})
 	sort.Stable(ByLabelName(labels))
 
+	// map ensures no duplicate label names.
+	l := make(map[string]string, maxLabelCount)
 	for _, label := range labels {
 		var finalKey = prometheustranslator.NormalizeLabel(label.Name)
 		if existingValue, alreadyExists := l[finalKey]; alreadyExists {
@@ -157,6 +165,13 @@ func createAttributes(resource pcommon.Resource, attributes pcommon.Map, externa
 		}
 	}
 
+	for _, lbl := range promotedAttrs {
+		normalized := prometheustranslator.NormalizeLabel(lbl.Name)
+		if _, exists := l[normalized]; !exists {
+			l[normalized] = lbl.Value
+		}
+	}
+
 	// Map service.name + service.namespace to job
 	if haveServiceName {
 		val := serviceName.AsString()
@@ -169,7 +184,7 @@ func createAttributes(resource pcommon.Resource, attributes pcommon.Map, externa
 	if haveInstanceID {
 		l[model.InstanceLabel] = instance.AsString()
 	}
-	for key, value := range externalLabels {
+	for key, value := range settings.ExternalLabels {
 		// External labels have already been sanitized
 		if _, alreadyExists := l[key]; alreadyExists {
 			// Skip external labels if they are overridden by metric attributes
@@ -232,7 +247,7 @@ func (c *PrometheusConverter) addHistogramDataPoints(dataPoints pmetric.Histogra
 	for x := 0; x < dataPoints.Len(); x++ {
 		pt := dataPoints.At(x)
 		timestamp := convertTimeStamp(pt.Timestamp())
-		baseLabels := createAttributes(resource, pt.Attributes(), settings.ExternalLabels, nil, false)
+		baseLabels := createAttributes(resource, pt.Attributes(), settings, nil, false)
 
 		// If the sum is unset, it indicates the _sum metric point should be
 		// omitted
@@ -408,7 +423,7 @@ func (c *PrometheusConverter) addSummaryDataPoints(dataPoints pmetric.SummaryDat
 	for x := 0; x < dataPoints.Len(); x++ {
 		pt := dataPoints.At(x)
 		timestamp := convertTimeStamp(pt.Timestamp())
-		baseLabels := createAttributes(resource, pt.Attributes(), settings.ExternalLabels, nil, false)
+		baseLabels := createAttributes(resource, pt.Attributes(), settings, nil, false)
 
 		// treat sum as a sample in an individual TimeSeries
 		sum := &prompb.Sample{
@@ -554,7 +569,8 @@ func addResourceTargetInfo(resource pcommon.Resource, settings Settings, timesta
 		name = settings.Namespace + "_" + name
 	}
 
-	labels := createAttributes(resource, attributes, settings.ExternalLabels, identifyingAttrs, false, model.MetricNameLabel, name)
+	settings.PromoteResourceAttributes = nil
+	labels := createAttributes(resource, attributes, settings, identifyingAttrs, false, model.MetricNameLabel, name)
 	haveIdentifier := false
 	for _, l := range labels {
 		if l.Name == model.JobLabel || l.Name == model.InstanceLabel {
diff --git a/storage/remote/otlptranslator/prometheusremotewrite/histograms.go b/storage/remote/otlptranslator/prometheusremotewrite/histograms.go
index 21b3f5dd9..73528019d 100644
--- a/storage/remote/otlptranslator/prometheusremotewrite/histograms.go
+++ b/storage/remote/otlptranslator/prometheusremotewrite/histograms.go
@@ -45,7 +45,7 @@ func (c *PrometheusConverter) addExponentialHistogramDataPoints(dataPoints pmetr
 		lbls := createAttributes(
 			resource,
 			pt.Attributes(),
-			settings.ExternalLabels,
+			settings,
 			nil,
 			true,
 			model.MetricNameLabel,
diff --git a/storage/remote/otlptranslator/prometheusremotewrite/metrics_to_prw.go b/storage/remote/otlptranslator/prometheusremotewrite/metrics_to_prw.go
index 65dac99c5..a3a789723 100644
--- a/storage/remote/otlptranslator/prometheusremotewrite/metrics_to_prw.go
+++ b/storage/remote/otlptranslator/prometheusremotewrite/metrics_to_prw.go
@@ -30,12 +30,13 @@ import (
 )
 
 type Settings struct {
-	Namespace           string
-	ExternalLabels      map[string]string
-	DisableTargetInfo   bool
-	ExportCreatedMetric bool
-	AddMetricSuffixes   bool
-	SendMetadata        bool
+	Namespace                 string
+	ExternalLabels            map[string]string
+	DisableTargetInfo         bool
+	ExportCreatedMetric       bool
+	AddMetricSuffixes         bool
+	SendMetadata              bool
+	PromoteResourceAttributes []string
 }
 
 // PrometheusConverter converts from OTel write format to Prometheus remote write format.
diff --git a/storage/remote/otlptranslator/prometheusremotewrite/number_data_points.go b/storage/remote/otlptranslator/prometheusremotewrite/number_data_points.go
index aafebc6c4..80ccb46c7 100644
--- a/storage/remote/otlptranslator/prometheusremotewrite/number_data_points.go
+++ b/storage/remote/otlptranslator/prometheusremotewrite/number_data_points.go
@@ -34,7 +34,7 @@ func (c *PrometheusConverter) addGaugeNumberDataPoints(dataPoints pmetric.Number
 		labels := createAttributes(
 			resource,
 			pt.Attributes(),
-			settings.ExternalLabels,
+			settings,
 			nil,
 			true,
 			model.MetricNameLabel,
@@ -64,7 +64,7 @@ func (c *PrometheusConverter) addSumNumberDataPoints(dataPoints pmetric.NumberDa
 		lbls := createAttributes(
 			resource,
 			pt.Attributes(),
-			settings.ExternalLabels,
+			settings,
 			nil,
 			true,
 			model.MetricNameLabel,
diff --git a/storage/remote/write_handler.go b/storage/remote/write_handler.go
index d82237371..b69504949 100644
--- a/storage/remote/write_handler.go
+++ b/storage/remote/write_handler.go
@@ -490,21 +490,23 @@ func (h *writeHandler) appendV2(app storage.Appender, req *writev2.Request, rs *
 
 // NewOTLPWriteHandler creates a http.Handler that accepts OTLP write requests and
 // writes them to the provided appendable.
-func NewOTLPWriteHandler(logger log.Logger, appendable storage.Appendable) http.Handler {
+func NewOTLPWriteHandler(logger log.Logger, appendable storage.Appendable, configFunc func() config.Config) http.Handler {
 	rwHandler := &writeHandler{
 		logger:     logger,
 		appendable: appendable,
 	}
 
 	return &otlpWriteHandler{
-		logger:    logger,
-		rwHandler: rwHandler,
+		logger:     logger,
+		rwHandler:  rwHandler,
+		configFunc: configFunc,
 	}
 }
 
 type otlpWriteHandler struct {
-	logger    log.Logger
-	rwHandler *writeHandler
+	logger     log.Logger
+	rwHandler  *writeHandler
+	configFunc func() config.Config
 }
 
 func (h *otlpWriteHandler) ServeHTTP(w http.ResponseWriter, r *http.Request) {
@@ -515,9 +517,12 @@ func (h *otlpWriteHandler) ServeHTTP(w http.ResponseWriter, r *http.Request) {
 		return
 	}
 
+	otlpCfg := h.configFunc().OTLPConfig
+
 	converter := otlptranslator.NewPrometheusConverter()
 	if err := converter.FromMetrics(req.Metrics(), otlptranslator.Settings{
-		AddMetricSuffixes: true,
+		AddMetricSuffixes:         true,
+		PromoteResourceAttributes: otlpCfg.PromoteResourceAttributes,
 	}); err != nil {
 		level.Warn(h.logger).Log("msg", "Error translating OTLP metrics to Prometheus write request", "err", err)
 	}
diff --git a/storage/remote/write_test.go b/storage/remote/write_test.go
index 6e7422a58..83dfffbae 100644
--- a/storage/remote/write_test.go
+++ b/storage/remote/write_test.go
@@ -379,7 +379,11 @@ func TestOTLPWriteHandler(t *testing.T) {
 	req.Header.Set("Content-Type", "application/x-protobuf")
 
 	appendable := &mockAppendable{}
-	handler := NewOTLPWriteHandler(nil, appendable)
+	handler := NewOTLPWriteHandler(nil, appendable, func() config.Config {
+		return config.Config{
+			OTLPConfig: config.DefaultOTLPConfig,
+		}
+	})
 
 	recorder := httptest.NewRecorder()
 	handler.ServeHTTP(recorder, req)
diff --git a/web/api/v1/api.go b/web/api/v1/api.go
index 03854787f..d58be211f 100644
--- a/web/api/v1/api.go
+++ b/web/api/v1/api.go
@@ -295,7 +295,7 @@ func NewAPI(
 		a.remoteWriteHandler = remote.NewWriteHandler(logger, registerer, ap, acceptRemoteWriteProtoMsgs)
 	}
 	if otlpEnabled {
-		a.otlpWriteHandler = remote.NewOTLPWriteHandler(logger, ap)
+		a.otlpWriteHandler = remote.NewOTLPWriteHandler(logger, ap, configFunc)
 	}
 
 	return a
diff --git a/web/api/v1/api_test.go b/web/api/v1/api_test.go
index 86a57ca08..ba38ddc97 100644
--- a/web/api/v1/api_test.go
+++ b/web/api/v1/api_test.go
@@ -359,6 +359,7 @@ var samplePrometheusCfg = config.Config{
 	ScrapeConfigs:      []*config.ScrapeConfig{},
 	RemoteWriteConfigs: []*config.RemoteWriteConfig{},
 	RemoteReadConfigs:  []*config.RemoteReadConfig{},
+	OTLPConfig:         config.OTLPConfig{},
 }
 
 var sampleFlagMap = map[string]string{